Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Nancy L. Chamberlin, PhD
Assistant Professor of Neurology, Harvard Medical School
Assistant Professor, Department of Neurology, Beth Israel Deaconess Medical Center
Inter-office Mail Address
HIM 820Email nchamber@caregroup.harvard.edu
Society Memberships
Society for NeuroscienceResearch Unit(s)
Systems Neurobiology Group, Beth Israel Deaconess Medical Center
Sleep and Sleep Apnea SCOR Group, Harvard Medical School
Sleep and Sleep Apnea SCOR Group, Harvard Medical School
Research Funding
NIH/NHLBI PI Reflex Hypoglossal Responses to Negative Pressure
Organon PI Effect of Ach-esterase inhibitors on tonic and phasic upper airway dilator activity
Organon PI Effect of Ach-esterase inhibitors on tonic and phasic upper airway dilator activity
Selected Publications
Alfille PH, Merritt C, Chamberlin NL, Eikermann M. Control of perioperative muscle strength during ambulatory surgery.
Curr Opin Anaesthesiol. 2009 Sep 11. [Epub ahead of print] [PMID: 19752726]
Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats.
Anesthesiology. 2009 Jun;110(6):1327-34. [PMID: 19417601]
Branco LG, Moreira TS, Guyenet PG, Lalley PM, Kawai A, Putnam RW, Chamberlin NL, Saper CB, Gourine AV, Kanamaru M, Homma I. Commentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites.
J Appl Physiol. 2009 Apr;106(4):1467-70. [PMID: 19336680]
Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing.
Br J Anaesth. 2008 Sep;101(3):344-9. Epub 2008 Jun 16. [PMID: 18559352]
Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia.
J Comp Neurol. 2008 Jun 1;508(4):648-62. [PMID: 18383504]
Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, Gautam S, White DP, Chamberlin NL. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing.
Anesthesiology. 2008 May;108(5):897-906. [PMID: 18431126]
Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL. Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function.
Anesthesiology. 2007 Oct;107(4):621-9. [PMID: 17893459]
Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A. The influence of aging on pharyngeal collapsibility during sleep.
Chest. 2007 Jun;131(6):1702-9. Epub 2007 Apr 5. [PMID: 17413053]
Eikermann M, Chamberlin NL, Gerber H, Malhotra A. Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily.
Crit Care Med. 2007 Jun;35(6):1634-5; author reply 1635. [PMID: 17522551]
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol 2007; 579(Pt 2):515-526. [PMID: 17185342]
Arrigoni E, Chamberlin NL, Saper CB, McCarley RW. Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Neuroscience. 2006 Jun 30;140(2):403-13. Epub 2006 Mar 20. [PMID: 16542780]
Reviews
Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea.
Expert Opin Ther Targets. 2009 Jul;13(7):795-809. Review. [PMID: 19530985]
Curr Opin Anaesthesiol. 2009 Sep 11. [Epub ahead of print] [PMID: 19752726]
Eikermann M, Fassbender P, Zaremba S, Jordan AS, Rosow C, Malhotra A, Chamberlin NL. Pentobarbital dose-dependently increases respiratory genioglossus muscle activity while impairing diaphragmatic function in anesthetized rats.
Anesthesiology. 2009 Jun;110(6):1327-34. [PMID: 19417601]
Branco LG, Moreira TS, Guyenet PG, Lalley PM, Kawai A, Putnam RW, Chamberlin NL, Saper CB, Gourine AV, Kanamaru M, Homma I. Commentaries on Viewpoint: Central chemoreception is a complex system function that involves multiple brain stem sites.
J Appl Physiol. 2009 Apr;106(4):1467-70. [PMID: 19336680]
Eikermann M, Zaremba S, Malhotra A, Jordan AS, Rosow C, Chamberlin NL. Neostigmine but not sugammadex impairs upper airway dilator muscle activity and breathing.
Br J Anaesth. 2008 Sep;101(3):344-9. Epub 2008 Jun 16. [PMID: 18559352]
Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia.
J Comp Neurol. 2008 Jun 1;508(4):648-62. [PMID: 18383504]
Eikermann M, Malhotra A, Fassbender P, Zaremba S, Jordan AS, Gautam S, White DP, Chamberlin NL. Differential effects of isoflurane and propofol on upper airway dilator muscle activity and breathing.
Anesthesiology. 2008 May;108(5):897-906. [PMID: 18431126]
Eikermann M, Fassbender P, Malhotra A, Takahashi M, Kubo S, Jordan AS, Gautam S, White DP, Chamberlin NL. Unwarranted administration of acetylcholinesterase inhibitors can impair genioglossus and diaphragm muscle function.
Anesthesiology. 2007 Oct;107(4):621-9. [PMID: 17893459]
Eikermann M, Jordan AS, Chamberlin NL, Gautam S, Wellman A, Lo YL, White DP, Malhotra A. The influence of aging on pharyngeal collapsibility during sleep.
Chest. 2007 Jun;131(6):1702-9. Epub 2007 Apr 5. [PMID: 17413053]
Eikermann M, Chamberlin NL, Gerber H, Malhotra A. Muscle weakness after administration of neuromuscular blocking agents: do not immobilize the diaphragm unnecessarily.
Crit Care Med. 2007 Jun;35(6):1634-5; author reply 1635. [PMID: 17522551]
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol 2007; 579(Pt 2):515-526. [PMID: 17185342]
Arrigoni E, Chamberlin NL, Saper CB, McCarley RW. Adenosine inhibits basal forebrain cholinergic and noncholinergic neurons in vitro.
Neuroscience. 2006 Jun 30;140(2):403-13. Epub 2006 Mar 20. [PMID: 16542780]
Reviews
Saboisky JP, Chamberlin NL, Malhotra A. Potential therapeutic targets in obstructive sleep apnoea.
Expert Opin Ther Targets. 2009 Jul;13(7):795-809. Review. [PMID: 19530985]
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