Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
J. Woodrow Weiss, MD
Associate Professor of Medicine, Harvard Medical School
Associate Physician, Department of Medicine, Beth Israel Deaconess Medical Center
Address
330 Brookline Avenue, Medicine – GZ405Boston, MA 02215
USA
Inter-office Mail Address
BIDMC – GZ409AFax 617-667-1604
Email gshaidan@bidmc.harvard.edu
Society Memberships
American Thoracic Society,American Federation for Clinical Research, Massachusetts Thoracic Society,
American Sleep Disorders Association,
American Physiology Society
Research Interests
Since completing my pulmonary fellowship I have focused most of my research, clinical, and administrative efforts on understanding and treating the consequences of upper airway obstruction during sleep. Over the last 15 years I have tried to concentrate my research efforts on understanding the impact of sleep-disordered breathing on cardiorespiratory control. My goal has been to elucidate the factors that contribute to the acute and, more importantly, the chronic cardiovascular changes that occur in patients with obstructive sleep apnea. This interest has led me to investigate the effect of sleep on the circulation. It has also led me to try to understand the changes in sympathetic nervous system activity that occur as a consequence of the dual insults of nocturnal hypoxia and sleep deprivation suffered by patients with sleep apnea. Much of this work has been carried out in patients suffering from this common illness. The limitations of human investigation have recently led us, however, to develop both a rodent and a human model of cyclic intermittent hypoxia. We are currently using these models to explore the mechanisms by which intermittent hypoxia produces sustained sympathoexcitation, diurnal hypertension, augmented ventilatory responsiveness to hypoxia, altered vascular function, and insulin resistance, all manifestations of sleep apnea.
Much of this investigation flowed naturally from my clinical efforts as Co-Director of the Sleep Disorders Center at Beth Israel Hospital/Beth Israel Deaconess Medical Center. The clinical physiological investigations, which have been the focus of most of my research career, could only happen with the active participation of my patients. Over the last 15 years the Sleep Center has developed into the largest clinical sleep program in Massachusetts. Sleep disorders medicine was a fledgling medical specialty when I completed my pulmonary fellowship. Now, however, it has become a major component of pulmonary (and neurology, psychiatry, pediatric, etc.) training. The growth of interest in this specialty has allowed me to interact with medical students, house staff, and community physicians as a clinical consultant and as an educator. These interactions led to my efforts to develop a comprehensive curriculum in sleep medicine for Harvard Medical School supported by a Sleep Academic Award from the National Institutes of Health. The experience of working on a curriculum program led me to develop a blueprint for a Harvard Medical School Division of Sleep Medicine, a school-wide Division for which I was the founder and served as the first Chair of the Faculty Executive Committee.
Much of this investigation flowed naturally from my clinical efforts as Co-Director of the Sleep Disorders Center at Beth Israel Hospital/Beth Israel Deaconess Medical Center. The clinical physiological investigations, which have been the focus of most of my research career, could only happen with the active participation of my patients. Over the last 15 years the Sleep Center has developed into the largest clinical sleep program in Massachusetts. Sleep disorders medicine was a fledgling medical specialty when I completed my pulmonary fellowship. Now, however, it has become a major component of pulmonary (and neurology, psychiatry, pediatric, etc.) training. The growth of interest in this specialty has allowed me to interact with medical students, house staff, and community physicians as a clinical consultant and as an educator. These interactions led to my efforts to develop a comprehensive curriculum in sleep medicine for Harvard Medical School supported by a Sleep Academic Award from the National Institutes of Health. The experience of working on a curriculum program led me to develop a blueprint for a Harvard Medical School Division of Sleep Medicine, a school-wide Division for which I was the founder and served as the first Chair of the Faculty Executive Committee.
Trainees
Erik Garpestad, MD 1990-1993
Sandrine Launois, MD, PhD 1992-1997
Amit Anand, MD 1996-2001
Stacey Beske, MD, PhD 2001-2003
Jorge Serrador, PhD 2001-2004
Geoffrey Gilmartin, MD 2003-2004
Renaud Tamisier, MD, PhD 2004-2002
Matthew Curley, MD 2004-2006
Sarah-Jane Lusina 2005-2006
En-Sheng Ji, MD, MS, PhD 2006-
Sandrine Launois, MD, PhD 1992-1997
Amit Anand, MD 1996-2001
Stacey Beske, MD, PhD 2001-2003
Jorge Serrador, PhD 2001-2004
Geoffrey Gilmartin, MD 2003-2004
Renaud Tamisier, MD, PhD 2004-2002
Matthew Curley, MD 2004-2006
Sarah-Jane Lusina 2005-2006
En-Sheng Ji, MD, MS, PhD 2006-
Research Funding
NIH, PI: Weiss, Time Domains of Sympathetic Activity following Hypoxia
NIH PI: J. Weiss, Carotid Mediators of Sympathoexcitation in Sleep Apnea
NIH, PI: J. Weiss, Vascular Function after Exposure of Humans to Hypoxia
NIH PI: J. Weiss, Carotid Mediators of Sympathoexcitation in Sleep Apnea
NIH, PI: J. Weiss, Vascular Function after Exposure of Humans to Hypoxia
Selected Publications
Tamisier R, B. Hunt, A. Anand, G. Gilmartin, M. Curley and J.W. Weiss. 8-hour Hemodynamics and Muscle Sympathetic Nerve Activity after 8 hours of Sustained Hypoxia in Healthy Humans.
Am J Physiol Heart Circ Physiol. In revision
B. Hunt, Tamisier R, A. Anand, G. Gilmartin, M. Curley and J.W. Weiss. Affect of Ventilatory Acclimatization on Baroreflex Responsiveness.
J Physiol (London). In revision
Huang J, Tamisier R, J. Tong, Weiss JW. Effect of Chronic Intermittent Hypoxia on nNOS mRNA and Protein Expression of the Hypothalamus in the Rats.
Respir Physiol Neurobiol. 2007 Aug 15;158(1):30-8. Epub 2007 Mar 18. [PMID: 17442632]
Matthew D. Weiss, Robert Joseph Thomas, Joseph E. Mietus, Chung-Kang Peng, Gilmartin G, Robert W. Daly, Ary L. Goldberger, Daniel J. Gottlieb. Predicting the failure of positive airway pressure titration using ECG-derived cardiopulmonary coupling spectrograms.
APSS-2007, HMS Curriculum Vitae Page 4 of 5 Submitted. 2007.
Gilmartin G S, Tamisier R, Anand A, Cunnington D, J W Weiss. Evidence Of Impaired Hypoxic Vasodilation After Intermediate Duration Hypoxic Exposure.
Am J Physiol Heart Circ Physiol. 2006;291:H2173-80. [PMID: 16648184]
Gilmartin G, Prabakar C, Curley M, Tamisier R, Weiss JW. Changes in Insulin Sensitivity in Human Subjects Exposed to 14 Nights of Hypoxia.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A195.
Lynch ME, Gilmartin G, Curley MJ, Tamisier R, Prabakar C, Weiss JW. Changes in Flow-Mediated Vasodilation after 2 weeks of Continuous vs. Cyclic Nocturnal Hypoxia in Humans.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A196.
Curley MJ, Gilmartin G, Prabakar C, Lynch ME, Tamisier R, Weiss JW. Changes in Sympathetic Nervous System Activity and Hemodynamics after 4 weeks of Cyclic, Nocturnal Hypoxia in Normal Volunteers.
Proceedings of the American Thoracic Society. 2006;3 (Abstracts):A195.
Lynch ME, Gilmartin GS, Curley MJ, Tamisier R, and Weiss JW. Changes in flow mediated vasodilation after two weeks of continuous vs. cyclic nocturnal hypoxia in humans.
Submitted for American Thoracic Society Annual Meeting 2006.
Tamisier R, Anand A, Nieto LM, Cunnington D, Weiss JW. Arterial pressure and muscle sympathetic nerve activity are increased after two hours of sustained but not cyclic hypoxia in healthy humans.
J. Appl Physiol, 2005: 98 (1): 343-9 [PMID: 15448121]
Tamisier R, Gilmartin G, Anand AN, Curley MJ, Weiss JW. Fourteen Days of Nocturnal Sustained Hypoxia Induces Increases in Muscle Sympathetic Nerve Activity (MSNA) and Arterial Blood Pressure in Normal Human Volunteers.
American Journal of Respiratory and Critical Care Medicine. 2005;2(Abstract Issue):A877.
Tamisier R, Gilmartin G, Curley M, Anand AN, Weiss JW. 8-Hour Poikilocapnic Hypoxia Causes Decreases in Muscle Sympathetic Nerve Activity (MSNA) and Blunted Vagal Baroreflex in Normal Human Volunteers.
American Journal of Critical Care Medicine. 2005;2(Abstract Issue):A878.
Ellenbogen JM, Hurford MO, Liebeskind DS, Neimark GB, Weiss D. Ventromedial frontal lobe trauma.
Neurology 2005;64:757.
Tamisier R, Nieto L, Anand A, Cunnington D, Weiss JW. Sustained muscle sympathetic activity after hypercapnic but not hypocapnic hypoxia in normal humans.
Respir Physiol Neurobiol. 2004, 141(2):145-155. [PMID: 15239965]
Tamisier R, Norman D, Anand A, Choi Y, Weiss JW. Evidence of sustained forearm vasodilation after brief isocapnic hypoxia.
J Appl Physiol. 2004: 96 (5): 1782-7. [PMID: 14766778]
Tamisier R, Anand A, Nieto LM, Cunnington D, Weiss JW. Resp Physiol Sustained muscle sympathetic nerve activity after hypercapnic but not hypocapnic hypoxia in normal humans.
Neurobiol, 2004: 141 (92): 145-55.
Patel SR, Celedon JC, Weiss ST, Palmer LJ. Lack of reproducibility of linkage results in serially measured blood pressure data.
BMC Genet 2003; 4 (Suppl 1): S37. [PMID: 14975105]
Palmer LJ, Scurrah KJ, Tobin M, Patel SR, Celedon JC, Burton PR, Weiss ST. Genome wide linkage analysis of longitudinal phenotypes using 2A random effects (SSARs) fitted by Gibbs sampling.
BMC Genet 2003; 4 (Suppl 1):S12
Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
J Pediatr 2003 Feb;142(2):163-8. [PMID: 12584538]
Anand A, Remsburg-Sailer S, Launois S, Weiss JW. Peripheral Vascular resistance increases following termination of obstructive apneas.
J Appl Physiol 2001: 91: 2359-65. [PMID: 11641381]
Anand A., Remsburg-Sailor S., Launois SH, Weiss J.W. Peripheral vascular resistance increases following termination of obstructive apneas.
J Appl Physiol, 2001, 91: 2359-2365. [PMID: 11641381]
Weiss JW, Launois S, Anand A. Cardio- respiratory changes in sleep disordered breathing.
Priniciples and Practice of Sleep Medicine, Edited by Kryger, Roth and Dement, 2000: 3rd Edition. 856-69.
Weiss JW, Launois S, Anand A and Garpestad E. Lung Biology in Health and Disease 2000: Sleep Apnea: Implications in cardiovascular and cerebrovascular disease: Marcel Dekker. Vol 146: 213-26. The acute hemodynamic response to upper airway obstruction during sleep.
Weiss JW, Launois S, Anand A and Garpestad E. Cardiovascular morbidity in obstructive sleep apnea.
Progress in Cardiovascular Diseases 1999: 41(5): 367-76. [PMID: 10406330]
Remsburg S., Launois SH, Weiss, J.W. Patients with obstructive sleep apnea have an abnormal peripheral vascular response to hypoxia.
J Appl Physiol, 1999, 87:1148-1153. [PMID: 10484589]
Kessler B., Anand A., Launois SH, Weiss J.W. Pharmacologically induced hypertension is associated with arousal from NREM sleep in normal volunteers.
J Appl Physiol, 1999, 87:897-901. [PMID: 10484555]
Launois SH, Abraham JH, Weiss JW, Kirby DA. Patterned cardiovascular responses to sleep and non respiratory arousals in a porcine model.
J Appl Physiol, 1998, 85:1285-1291. [PMID: 9760318]
Weiss JW, Remsburg S, Garpestad E, Ringler J, Sparrow D, Parker JA. Hemodynamic consequences of obstructive sleep apnea.
Sleep, 1996; 19:388-397. [PMID: 8843530]
Garpestad E, Ringler J, Parker JA, Remsburg S, Weiss JW. Sleep stage influences the hemodynamic response to obstructive apneas.
Am J Respir Crit Care Med, 1995; 152:199-203. [PMID: 7599824]
Kirby DA, Pinto JM, Weiss JW, Garpestad E, Zinkovska S. Effects of beta adrenergic receptor blockade on hemodynamic changes associated with obstructive sleep apnea.
Physiol Behav, 1995; 58:919-923. [PMID: 8577888]
Ringler J, Garpestad E, Basner RC, Weiss JW. Systemic blood pressure elevation after Airway occlusion during NREM sleep.
Am J Respir Crit Care Med, 1994; 150:1062-1066. [PMID: 7921437]
Garpestad E, Parker JA, Katayama H, Lilly J, Yasuda T, Ringler J, Strauss HW, Weiss JW. Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation.
J Appl Physiol, 1994; 77:1602-1608. [PMID: 7836175]
Pinto JMB, Garpestad E, Weiss JW, Bergau DM, Kirby DA. Hemodynamic changes associated with obstructive sleep apnea followed by arousal in a porcine model.
J Appl Physiol, 1993; 75:1439-1443. [PMID: 8282587]
Weiss JW, Garpestad E, Parker T, Remsburg S, Ringler J. Changes in Left ventricular stroke volume during obstructive apneas.
Sleep, 1993; 16:39-40. [PMID: 8178022]
Basner C, Ringler J, Garpestad E, Schwartzstein RM, Weinberger SE, Sparrow D, Lilly J, Weiss JW. Upper airway anesthesia delays arousal from inspiratory airway occlusion induced during human non-REM sleep.
J Appl Physiol, 1992; 73:642-648. [PMID: 1399992]
Garpestad E, Katayama H, Parker JA, Ringler J, Lilly J, Yasuda T, Moore RH, Strauss HW, Weiss JW. Stroke volume and cardiac output decreases at Termination of obstructive apnea. J Appl Physio, 1992; 73:1743-1748 [PMID: 1474046]
Garpestad E, Basner RC, Ringler J, Lilly J, Schwartzstein R, Weinberger SE, Weiss JW. Phenylephrine induced Hypertension decreases genioglossus EMG activity in awake humans.
J Appl Physio, 1992; 72:110-115. [PMID: 1537703]
Am J Physiol Heart Circ Physiol. In revision
B. Hunt, Tamisier R, A. Anand, G. Gilmartin, M. Curley and J.W. Weiss. Affect of Ventilatory Acclimatization on Baroreflex Responsiveness.
J Physiol (London). In revision
Huang J, Tamisier R, J. Tong, Weiss JW. Effect of Chronic Intermittent Hypoxia on nNOS mRNA and Protein Expression of the Hypothalamus in the Rats.
Respir Physiol Neurobiol. 2007 Aug 15;158(1):30-8. Epub 2007 Mar 18. [PMID: 17442632]
Matthew D. Weiss, Robert Joseph Thomas, Joseph E. Mietus, Chung-Kang Peng, Gilmartin G, Robert W. Daly, Ary L. Goldberger, Daniel J. Gottlieb. Predicting the failure of positive airway pressure titration using ECG-derived cardiopulmonary coupling spectrograms.
APSS-2007, HMS Curriculum Vitae Page 4 of 5 Submitted. 2007.
Gilmartin G S, Tamisier R, Anand A, Cunnington D, J W Weiss. Evidence Of Impaired Hypoxic Vasodilation After Intermediate Duration Hypoxic Exposure.
Am J Physiol Heart Circ Physiol. 2006;291:H2173-80. [PMID: 16648184]
Gilmartin G, Prabakar C, Curley M, Tamisier R, Weiss JW. Changes in Insulin Sensitivity in Human Subjects Exposed to 14 Nights of Hypoxia.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A195.
Lynch ME, Gilmartin G, Curley MJ, Tamisier R, Prabakar C, Weiss JW. Changes in Flow-Mediated Vasodilation after 2 weeks of Continuous vs. Cyclic Nocturnal Hypoxia in Humans.
Proceedings of the American Thoracic Society. 2006;3(Abstracts):A196.
Curley MJ, Gilmartin G, Prabakar C, Lynch ME, Tamisier R, Weiss JW. Changes in Sympathetic Nervous System Activity and Hemodynamics after 4 weeks of Cyclic, Nocturnal Hypoxia in Normal Volunteers.
Proceedings of the American Thoracic Society. 2006;3 (Abstracts):A195.
Lynch ME, Gilmartin GS, Curley MJ, Tamisier R, and Weiss JW. Changes in flow mediated vasodilation after two weeks of continuous vs. cyclic nocturnal hypoxia in humans.
Submitted for American Thoracic Society Annual Meeting 2006.
Tamisier R, Anand A, Nieto LM, Cunnington D, Weiss JW. Arterial pressure and muscle sympathetic nerve activity are increased after two hours of sustained but not cyclic hypoxia in healthy humans.
J. Appl Physiol, 2005: 98 (1): 343-9 [PMID: 15448121]
Tamisier R, Gilmartin G, Anand AN, Curley MJ, Weiss JW. Fourteen Days of Nocturnal Sustained Hypoxia Induces Increases in Muscle Sympathetic Nerve Activity (MSNA) and Arterial Blood Pressure in Normal Human Volunteers.
American Journal of Respiratory and Critical Care Medicine. 2005;2(Abstract Issue):A877.
Tamisier R, Gilmartin G, Curley M, Anand AN, Weiss JW. 8-Hour Poikilocapnic Hypoxia Causes Decreases in Muscle Sympathetic Nerve Activity (MSNA) and Blunted Vagal Baroreflex in Normal Human Volunteers.
American Journal of Critical Care Medicine. 2005;2(Abstract Issue):A878.
Ellenbogen JM, Hurford MO, Liebeskind DS, Neimark GB, Weiss D. Ventromedial frontal lobe trauma.
Neurology 2005;64:757.
Tamisier R, Nieto L, Anand A, Cunnington D, Weiss JW. Sustained muscle sympathetic activity after hypercapnic but not hypocapnic hypoxia in normal humans.
Respir Physiol Neurobiol. 2004, 141(2):145-155. [PMID: 15239965]
Tamisier R, Norman D, Anand A, Choi Y, Weiss JW. Evidence of sustained forearm vasodilation after brief isocapnic hypoxia.
J Appl Physiol. 2004: 96 (5): 1782-7. [PMID: 14766778]
Tamisier R, Anand A, Nieto LM, Cunnington D, Weiss JW. Resp Physiol Sustained muscle sympathetic nerve activity after hypercapnic but not hypocapnic hypoxia in normal humans.
Neurobiol, 2004: 141 (92): 145-55.
Patel SR, Celedon JC, Weiss ST, Palmer LJ. Lack of reproducibility of linkage results in serially measured blood pressure data.
BMC Genet 2003; 4 (Suppl 1): S37. [PMID: 14975105]
Palmer LJ, Scurrah KJ, Tobin M, Patel SR, Celedon JC, Burton PR, Weiss ST. Genome wide linkage analysis of longitudinal phenotypes using 2A random effects (SSARs) fitted by Gibbs sampling.
BMC Genet 2003; 4 (Suppl 1):S12
Pillar G, Schuscheim G, Weiss R, Malhotra A, McCowen KC, Shlitner A, Peled N, Shehadeh N. Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus.
J Pediatr 2003 Feb;142(2):163-8. [PMID: 12584538]
Anand A, Remsburg-Sailer S, Launois S, Weiss JW. Peripheral Vascular resistance increases following termination of obstructive apneas.
J Appl Physiol 2001: 91: 2359-65. [PMID: 11641381]
Anand A., Remsburg-Sailor S., Launois SH, Weiss J.W. Peripheral vascular resistance increases following termination of obstructive apneas.
J Appl Physiol, 2001, 91: 2359-2365. [PMID: 11641381]
Weiss JW, Launois S, Anand A. Cardio- respiratory changes in sleep disordered breathing.
Priniciples and Practice of Sleep Medicine, Edited by Kryger, Roth and Dement, 2000: 3rd Edition. 856-69.
Weiss JW, Launois S, Anand A and Garpestad E. Lung Biology in Health and Disease 2000: Sleep Apnea: Implications in cardiovascular and cerebrovascular disease: Marcel Dekker. Vol 146: 213-26. The acute hemodynamic response to upper airway obstruction during sleep.
Weiss JW, Launois S, Anand A and Garpestad E. Cardiovascular morbidity in obstructive sleep apnea.
Progress in Cardiovascular Diseases 1999: 41(5): 367-76. [PMID: 10406330]
Remsburg S., Launois SH, Weiss, J.W. Patients with obstructive sleep apnea have an abnormal peripheral vascular response to hypoxia.
J Appl Physiol, 1999, 87:1148-1153. [PMID: 10484589]
Kessler B., Anand A., Launois SH, Weiss J.W. Pharmacologically induced hypertension is associated with arousal from NREM sleep in normal volunteers.
J Appl Physiol, 1999, 87:897-901. [PMID: 10484555]
Launois SH, Abraham JH, Weiss JW, Kirby DA. Patterned cardiovascular responses to sleep and non respiratory arousals in a porcine model.
J Appl Physiol, 1998, 85:1285-1291. [PMID: 9760318]
Weiss JW, Remsburg S, Garpestad E, Ringler J, Sparrow D, Parker JA. Hemodynamic consequences of obstructive sleep apnea.
Sleep, 1996; 19:388-397. [PMID: 8843530]
Garpestad E, Ringler J, Parker JA, Remsburg S, Weiss JW. Sleep stage influences the hemodynamic response to obstructive apneas.
Am J Respir Crit Care Med, 1995; 152:199-203. [PMID: 7599824]
Kirby DA, Pinto JM, Weiss JW, Garpestad E, Zinkovska S. Effects of beta adrenergic receptor blockade on hemodynamic changes associated with obstructive sleep apnea.
Physiol Behav, 1995; 58:919-923. [PMID: 8577888]
Ringler J, Garpestad E, Basner RC, Weiss JW. Systemic blood pressure elevation after Airway occlusion during NREM sleep.
Am J Respir Crit Care Med, 1994; 150:1062-1066. [PMID: 7921437]
Garpestad E, Parker JA, Katayama H, Lilly J, Yasuda T, Ringler J, Strauss HW, Weiss JW. Decrease in ventricular stroke volume at apnea termination is independent of oxygen desaturation.
J Appl Physiol, 1994; 77:1602-1608. [PMID: 7836175]
Pinto JMB, Garpestad E, Weiss JW, Bergau DM, Kirby DA. Hemodynamic changes associated with obstructive sleep apnea followed by arousal in a porcine model.
J Appl Physiol, 1993; 75:1439-1443. [PMID: 8282587]
Weiss JW, Garpestad E, Parker T, Remsburg S, Ringler J. Changes in Left ventricular stroke volume during obstructive apneas.
Sleep, 1993; 16:39-40. [PMID: 8178022]
Basner C, Ringler J, Garpestad E, Schwartzstein RM, Weinberger SE, Sparrow D, Lilly J, Weiss JW. Upper airway anesthesia delays arousal from inspiratory airway occlusion induced during human non-REM sleep.
J Appl Physiol, 1992; 73:642-648. [PMID: 1399992]
Garpestad E, Katayama H, Parker JA, Ringler J, Lilly J, Yasuda T, Moore RH, Strauss HW, Weiss JW. Stroke volume and cardiac output decreases at Termination of obstructive apnea. J Appl Physio, 1992; 73:1743-1748 [PMID: 1474046]
Garpestad E, Basner RC, Ringler J, Lilly J, Schwartzstein R, Weinberger SE, Weiss JW. Phenylephrine induced Hypertension decreases genioglossus EMG activity in awake humans.
J Appl Physio, 1992; 72:110-115. [PMID: 1537703]
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