Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
Janet Mullington, PhD
Associate Professor of Neurology, Harvard Medical School
Associate Professor, Department of Neurology, Beth Israel Deaconess Medical Center
Address
330 Brookline Ave, Human Sleep and Chronobiology Research UnitDA-779
Boston, MA 02115
USA
Phone 617-667-0434
Fax 617-667-5210
Email jmulling@bidmc.harvard.edu
Society Memberships
Sleep Research SocietyAmerican Academy of Sleep Medicine
Canadian Sleep Society
European Sleep Research Society
Society for Neuroscience
Endocrine Society
Research Unit(s)
Human Sleep & Chronobiology Research Unit
Systems Neurobiology Group
Division of Sleep Medicine
Systems Neurobiology Group
Division of Sleep Medicine
Trainees
Maria Toth, MD, PhD
Research Funding
NIH/NHLBI, PI: Adiposity, BP and the Inflammatory Response to Sleep Loss
Selected Publications
Yano K, Liaw PC, Mullington JM, Shih SC, Okada H, Bodyak N, Kang PM, Toltl L, Belikoff B, Buras J, Simms BT, Mizgerd JP, Carmeliet P, Karumanchi SA, Aird WC. Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality.
J Exp Med. 2006 Jun 12;203(6):1447-58. Epub 2006 May 15. [PMID: 16702604]
Casement MD, Broussard JL, Mullington JM, Press DZ. The contribution of sleep to improvements in working memory scanning speed: a study of prolonged sleep restriction.
Biol Psychol. 2006 May;72(2):208-12. Epub 2005 Dec 27. [PMID: 16384630]
Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being.
Pain. 2005 Dec 15;119(1-3):56-64. Epub 2005 Nov 16. [PMID: 16297554]
Schuld A, Haack M, Hinze-Selch D, Mullington J, Pollmacher T. Experimental studies on the interaction between sleep and the immune system in humans.
Psychother Psychosom Med Psychol. 2005 Jan;55(1):29-35. Review. German. [PMID: 15647993]
Haack M, Pollmacher T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers.
Brain Behav Immun. 2004 Jul;18(4):361-7. [PMID: 15157953]
Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.
J Am Coll Cardiol. 2004 Feb 18;43(4):678-83. [PMID: 14975482]
Mullington JM, Chan JL, Van Dongen HP, Szuba MP, Samaras J, Price NJ, Meier-Ewert HK, Dinges DF, Mantzoros CS. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men.
J Neuroendocrinol. 2003 Sep;15(9):851-4. [PMID: 12899679]
Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.
Sleep. 2003 Mar 15;26(2):117-26. Erratum in: Sleep. 2004 Jun 15;27(4):600. [PMID: 12683469]
Straub RH, Schuld A, Mullington J, Haack M, Scholmerich J, Pollmacher T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects.
J Endocrinol. 2002 Nov;175(2):467-74. [PMID: 12429044]
Van Dongen HP, Price NJ, Mullington JM, Szuba MP, Kapoor SC, Dinges DF. Caffeine eliminates psychomotor vigilance deficits from sleep inertia.
Sleep. 2001 Nov 1;24(7):813-9. [PMID: 11683484]
Mullington JM, Hinze-Selch D, Pollmacher T. Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.
Ann N Y Acad Sci. 2001 Mar;933:201-10. Review. [PMID: 12000021]
Meier-Ewert HK, Ridker PM, Rifai N, Price N, Dinges DF, Mullington JM. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects.
Clin Chem. 2001 Mar;47(3):426-30. [PMID: 11238292]
Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight.
J Allergy Clin Immunol. 2001 Jan;107(1):165-70. [PMID: 11150007]
Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, Pollmacher T. Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers.
J Clin Endocrinol Metab. 2000 Dec;85(12):4624-9. [PMID: 11134118]
Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmacher T. Dose-dependent effects of endotoxin on human sleep.
Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R947-55. [PMID: 10749783]
Pollmacher T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. Experimental immunomodulation, sleep, and sleepiness in humans.
Ann N Y Acad Sci. 2000;917:488-99. Review. [PMID: 11268376]
Schuld A, Mullington J, Hermann D, Hinze-Selch D, Fenzel T, Holsboer F, Pollmacher T. Effects of granulocyte colony-stimulating factor on night sleep in humans.
Am J Physiol. 1999 Apr;276(4 Pt 2):R1149-55. [PMID: 10198397]
Pollmacher T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans.
J Infect Dis. 1999 Apr;179(4):1047-8. No abstract available. [PMID: 10068609]
Hinze-Selch D, Becker EW, Stein GM, Berg PA, Mullington J, Holsboer F, Pollmacher T. Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients.
Neuropsychopharmacology. 1998 Aug;19(2):114-22. [PMID: 9629565]
Hermann DM, Mullington J, Hinze-Selch D, Schreiber W, Galanos C, Pollmacher T. Endotoxin-induced changes in sleep and sleepiness during the day.
Psychoneuroendocrinology. 1998 Jul;23(5):427-37. [PMID: 9802118]
Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J, Wekerle H, Holsboer F, Pollmacher T. In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls.
Neurology. 1998 Apr;50(4):1149-52. [PMID: 9566413]
Broughton R, Krupa S, Boucher B, Rivers M, Mullington J. Impaired circadian waking arousal in narcolepsy-cataplexy.
Sleep Res Online. 1998;1(4):159-65. [PMID: 11382873]
Pollmacher T, Hinze-Selch D, Fenzel T, Kraus T, Schuld A, Mullington J. Plasma levels of cytokines and soluble cytokine receptors during treatment with haloperidol.
Am J Psychiatry. 1997 Dec;154(12):1763-5. [PMID: 9396961]
Pollmacher T, Mullington J, Lauer CJ. REM sleep disinhibition at sleep onset: a comparison between narcolepsy and depression.
Biol Psychiatry. 1997 Oct 15;42(8):713-20. [PMID: 9325565]
Hinze-Selch D, Mullington J, Orth A, Lauer CJ, Pollmacher T. Effects of clozapine on sleep: a longitudinal study.
Biol Psychiatry. 1997 Aug 15;42(4):260-6. [PMID: 9270902]
Pollmacher T, Fenzel T, Mullington J, Hinze-Selch D. The influence of clozapine treatment on plasma granulocyte colony-stimulating (G-CSF) levels.
Pharmacopsychiatry. 1997 Jul;30(4):118-21. [PMID: 9271776]
Pollmacher T, Hinze-Selch D, Mullington J, Fenzel T, Holsboer F. Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia.
Arch Gen Psychiatry. 1997 Jan;54(1):89-90. No abstract available. [PMID: 9006405]
Pollmacher T, Mullington J, Korth C, Schreiber W, Hermann D, Orth A, Galanos C, Holsboer F. Diurnal variations in the human host response to endotoxin.
J Infect Dis. 1996 Nov;174(5):1040-5. [PMID: 8896506]
Pollmacher T, Korth C, Schreiber W, Hermann D, Mullington J. Effects of repeated administration of granulocyte colony-stimulating factor (G-CSF) on neutrophil counts, plasma cytokine, and cytokine receptor levels.
Cytokine. 1996 Oct;8(10):799-803. [PMID: 8980882]
Pollmacher T, Hinze-Selch D, Mullington J. Effects of clozapine on plasma cytokine and soluble cytokine receptor levels.
J Clin Psychopharmacol. 1996 Oct;16(5):403-9. [PMID: 8889915]
Mullington J, Hermann D, Holsboer F, Pollmacher T. Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.
Neuroendocrinology. 1996 Sep;64(3):233-41. [PMID: 8875441]
Korth C, Mullington J, Schreiber W, Pollmacher T. Influence of endotoxin on daytime sleep in humans.
Infect Immun. 1996 Apr;64(4):1110-15. [PMID: 8606066]
Pollmacher T, Korth C, Mullington J, Schreiber W, Sauer J, Vedder H, Galanos C, Holsboer F. Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men.
Blood. 1996 Feb 1;87(3):900-5. [PMID: 8562960]
Hinze-Selch D, Mullington J, Pollmacher T. Clozapine, cytokines, fever and sleep.
Wien Med Wochenschr. 1996;146(13-14):311-3. German. [PMID: 9012164]
Hinze-Selch D, Mullington J, Pollmacher T. Sleep during clozapine-induced fever in a schizophrenic patient.
Biol Psychiatry. 1995 Nov 15;38(10):690-3. No abstract available. [PMID: 8555381]
Pollmacher T, Hinze-Selch D, Mullington J, Holsboer F. Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors.
Arch Gen Psychiatry. 1995 Oct;52(10):877-8. No abstract available. [PMID: 7575109]
Pollmacher T, Mullington J, Korth C, Hinze-Selch D. Influence of host defense activation on sleep in humans.
Adv Neuroimmunol. 1995;5(2):155-69. Review. [PMID: 7496610]
Broughton R, Mullington J. Chronobiological aspects of narcolepsy.
Sleep. 1994 Dec;17(8 Suppl):S35-44. Review. [PMID: 7701198]
Mullington J, Broughton R. Daytime sleep inertia in narcolepsy-cataplexy.
Sleep. 1994 Feb;17(1):69-76. [PMID: 8191205]
Mullington J, Broughton R. Scheduled naps in the management of daytime sleepiness in narcolepsy-cataplexy.
Sleep. 1993 Aug;16(5):444-56. [PMID: 8378686]
Broughton R, Mullington J. Circasemidian sleep propensity and the phase-amplitude maintenance model of human sleep/wake regulation.
J Sleep Res. 1992 Jun;1(2):93-98. [PMID: 10607032]
Purcell S, Mullington J, Moffitt A, Hoffmann R, Pigeau R. Dream self-reflectiveness as a learned cognitive skill.
Sleep. 1986;9(3):423-37. [PMID: 3764289]
J Exp Med. 2006 Jun 12;203(6):1447-58. Epub 2006 May 15. [PMID: 16702604]
Casement MD, Broussard JL, Mullington JM, Press DZ. The contribution of sleep to improvements in working memory scanning speed: a study of prolonged sleep restriction.
Biol Psychol. 2006 May;72(2):208-12. Epub 2005 Dec 27. [PMID: 16384630]
Haack M, Mullington JM. Sustained sleep restriction reduces emotional and physical well-being.
Pain. 2005 Dec 15;119(1-3):56-64. Epub 2005 Nov 16. [PMID: 16297554]
Schuld A, Haack M, Hinze-Selch D, Mullington J, Pollmacher T. Experimental studies on the interaction between sleep and the immune system in humans.
Psychother Psychosom Med Psychol. 2005 Jan;55(1):29-35. Review. German. [PMID: 15647993]
Haack M, Pollmacher T, Mullington JM. Diurnal and sleep-wake dependent variations of soluble TNF- and IL-2 receptors in healthy volunteers.
Brain Behav Immun. 2004 Jul;18(4):361-7. [PMID: 15157953]
Meier-Ewert HK, Ridker PM, Rifai N, Regan MM, Price NJ, Dinges DF, Mullington JM. Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk.
J Am Coll Cardiol. 2004 Feb 18;43(4):678-83. [PMID: 14975482]
Mullington JM, Chan JL, Van Dongen HP, Szuba MP, Samaras J, Price NJ, Meier-Ewert HK, Dinges DF, Mantzoros CS. Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men.
J Neuroendocrinol. 2003 Sep;15(9):851-4. [PMID: 12899679]
Van Dongen HP, Maislin G, Mullington JM, Dinges DF. The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation.
Sleep. 2003 Mar 15;26(2):117-26. Erratum in: Sleep. 2004 Jun 15;27(4):600. [PMID: 12683469]
Straub RH, Schuld A, Mullington J, Haack M, Scholmerich J, Pollmacher T. The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects.
J Endocrinol. 2002 Nov;175(2):467-74. [PMID: 12429044]
Van Dongen HP, Price NJ, Mullington JM, Szuba MP, Kapoor SC, Dinges DF. Caffeine eliminates psychomotor vigilance deficits from sleep inertia.
Sleep. 2001 Nov 1;24(7):813-9. [PMID: 11683484]
Mullington JM, Hinze-Selch D, Pollmacher T. Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.
Ann N Y Acad Sci. 2001 Mar;933:201-10. Review. [PMID: 12000021]
Meier-Ewert HK, Ridker PM, Rifai N, Price N, Dinges DF, Mullington JM. Absence of diurnal variation of C-reactive protein concentrations in healthy human subjects.
Clin Chem. 2001 Mar;47(3):426-30. [PMID: 11238292]
Shearer WT, Reuben JM, Mullington JM, Price NJ, Lee BN, Smith EO, Szuba MP, Van Dongen HP, Dinges DF. Soluble TNF-alpha receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight.
J Allergy Clin Immunol. 2001 Jan;107(1):165-70. [PMID: 11150007]
Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, Pollmacher T. Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers.
J Clin Endocrinol Metab. 2000 Dec;85(12):4624-9. [PMID: 11134118]
Mullington J, Korth C, Hermann DM, Orth A, Galanos C, Holsboer F, Pollmacher T. Dose-dependent effects of endotoxin on human sleep.
Am J Physiol Regul Integr Comp Physiol. 2000 Apr;278(4):R947-55. [PMID: 10749783]
Pollmacher T, Schuld A, Kraus T, Haack M, Hinze-Selch D, Mullington J. Experimental immunomodulation, sleep, and sleepiness in humans.
Ann N Y Acad Sci. 2000;917:488-99. Review. [PMID: 11268376]
Schuld A, Mullington J, Hermann D, Hinze-Selch D, Fenzel T, Holsboer F, Pollmacher T. Effects of granulocyte colony-stimulating factor on night sleep in humans.
Am J Physiol. 1999 Apr;276(4 Pt 2):R1149-55. [PMID: 10198397]
Pollmacher T, Kraus T, Haack M, Uhr M, Mullington J. Salmonella abortus equi endotoxin does not affect leptin plasma levels in healthy humans.
J Infect Dis. 1999 Apr;179(4):1047-8. No abstract available. [PMID: 10068609]
Hinze-Selch D, Becker EW, Stein GM, Berg PA, Mullington J, Holsboer F, Pollmacher T. Effects of clozapine on in vitro immune parameters: a longitudinal study in clozapine-treated schizophrenic patients.
Neuropsychopharmacology. 1998 Aug;19(2):114-22. [PMID: 9629565]
Hermann DM, Mullington J, Hinze-Selch D, Schreiber W, Galanos C, Pollmacher T. Endotoxin-induced changes in sleep and sleepiness during the day.
Psychoneuroendocrinology. 1998 Jul;23(5):427-37. [PMID: 9802118]
Hinze-Selch D, Wetter TC, Zhang Y, Lu HC, Albert ED, Mullington J, Wekerle H, Holsboer F, Pollmacher T. In vivo and in vitro immune variables in patients with narcolepsy and HLA-DR2 matched controls.
Neurology. 1998 Apr;50(4):1149-52. [PMID: 9566413]
Broughton R, Krupa S, Boucher B, Rivers M, Mullington J. Impaired circadian waking arousal in narcolepsy-cataplexy.
Sleep Res Online. 1998;1(4):159-65. [PMID: 11382873]
Pollmacher T, Hinze-Selch D, Fenzel T, Kraus T, Schuld A, Mullington J. Plasma levels of cytokines and soluble cytokine receptors during treatment with haloperidol.
Am J Psychiatry. 1997 Dec;154(12):1763-5. [PMID: 9396961]
Pollmacher T, Mullington J, Lauer CJ. REM sleep disinhibition at sleep onset: a comparison between narcolepsy and depression.
Biol Psychiatry. 1997 Oct 15;42(8):713-20. [PMID: 9325565]
Hinze-Selch D, Mullington J, Orth A, Lauer CJ, Pollmacher T. Effects of clozapine on sleep: a longitudinal study.
Biol Psychiatry. 1997 Aug 15;42(4):260-6. [PMID: 9270902]
Pollmacher T, Fenzel T, Mullington J, Hinze-Selch D. The influence of clozapine treatment on plasma granulocyte colony-stimulating (G-CSF) levels.
Pharmacopsychiatry. 1997 Jul;30(4):118-21. [PMID: 9271776]
Pollmacher T, Hinze-Selch D, Mullington J, Fenzel T, Holsboer F. Smoking affects plasma-soluble interleukin-2 receptor levels in patients with schizophrenia.
Arch Gen Psychiatry. 1997 Jan;54(1):89-90. No abstract available. [PMID: 9006405]
Pollmacher T, Mullington J, Korth C, Schreiber W, Hermann D, Orth A, Galanos C, Holsboer F. Diurnal variations in the human host response to endotoxin.
J Infect Dis. 1996 Nov;174(5):1040-5. [PMID: 8896506]
Pollmacher T, Korth C, Schreiber W, Hermann D, Mullington J. Effects of repeated administration of granulocyte colony-stimulating factor (G-CSF) on neutrophil counts, plasma cytokine, and cytokine receptor levels.
Cytokine. 1996 Oct;8(10):799-803. [PMID: 8980882]
Pollmacher T, Hinze-Selch D, Mullington J. Effects of clozapine on plasma cytokine and soluble cytokine receptor levels.
J Clin Psychopharmacol. 1996 Oct;16(5):403-9. [PMID: 8889915]
Mullington J, Hermann D, Holsboer F, Pollmacher T. Age-dependent suppression of nocturnal growth hormone levels during sleep deprivation.
Neuroendocrinology. 1996 Sep;64(3):233-41. [PMID: 8875441]
Korth C, Mullington J, Schreiber W, Pollmacher T. Influence of endotoxin on daytime sleep in humans.
Infect Immun. 1996 Apr;64(4):1110-15. [PMID: 8606066]
Pollmacher T, Korth C, Mullington J, Schreiber W, Sauer J, Vedder H, Galanos C, Holsboer F. Effects of granulocyte colony-stimulating factor on plasma cytokine and cytokine receptor levels and on the in vivo host response to endotoxin in healthy men.
Blood. 1996 Feb 1;87(3):900-5. [PMID: 8562960]
Hinze-Selch D, Mullington J, Pollmacher T. Clozapine, cytokines, fever and sleep.
Wien Med Wochenschr. 1996;146(13-14):311-3. German. [PMID: 9012164]
Hinze-Selch D, Mullington J, Pollmacher T. Sleep during clozapine-induced fever in a schizophrenic patient.
Biol Psychiatry. 1995 Nov 15;38(10):690-3. No abstract available. [PMID: 8555381]
Pollmacher T, Hinze-Selch D, Mullington J, Holsboer F. Clozapine-induced increase in plasma levels of soluble interleukin-2 receptors.
Arch Gen Psychiatry. 1995 Oct;52(10):877-8. No abstract available. [PMID: 7575109]
Pollmacher T, Mullington J, Korth C, Hinze-Selch D. Influence of host defense activation on sleep in humans.
Adv Neuroimmunol. 1995;5(2):155-69. Review. [PMID: 7496610]
Broughton R, Mullington J. Chronobiological aspects of narcolepsy.
Sleep. 1994 Dec;17(8 Suppl):S35-44. Review. [PMID: 7701198]
Mullington J, Broughton R. Daytime sleep inertia in narcolepsy-cataplexy.
Sleep. 1994 Feb;17(1):69-76. [PMID: 8191205]
Mullington J, Broughton R. Scheduled naps in the management of daytime sleepiness in narcolepsy-cataplexy.
Sleep. 1993 Aug;16(5):444-56. [PMID: 8378686]
Broughton R, Mullington J. Circasemidian sleep propensity and the phase-amplitude maintenance model of human sleep/wake regulation.
J Sleep Res. 1992 Jun;1(2):93-98. [PMID: 10607032]
Purcell S, Mullington J, Moffitt A, Hoffmann R, Pigeau R. Dream self-reflectiveness as a learned cognitive skill.
Sleep. 1986;9(3):423-37. [PMID: 3764289]
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