Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
David P. White, MD
Gerald E. McGinnis Professor of Sleep Medicine, Harvard Medical School
Senior Physician, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Society Memberships
American Academy of Sleep MedicineAmerican Thoracic Society
American Society for Clinical Investigation
American Association of Physicians
Research Unit(s)
Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women's Hospital
Research Interests
The research in my laboratory primarily addresses understanding the pathophysiology of obstructive sleep apnea and other disorders of breathing during sleep. In approaching this disorder there are three principal areas of investigation: 1) airway anatomy, 2) upper airway muscle control, and 3) the general control of breathing. First, regarding upper airway anatomy, we have previously and are currently studying the airway using MRI and CT methodologies with a particular focus on the influence of aging, obesity and androgens on pharyngeal anatomy. We have also developed a computational (finite element) model of the human upper airway to aid in understanding physiology and to develop new therapies. Second, motor control of the upper airway has been the principal focus of my laboratory for at least the last 10 years. We have defined the normal activation pattern and function of a number of pharyngeal muscles and subsequently determined the influence of state (sleep) on these muscles. Muscle performance in patients with sleep apnea has also been compared to normal controls in defining the pathophysiology of airway collapse during sleep. How these muscles respond to standard respiratory stimuli (chemistry, negative pressure) has also been defined awake and asleep. Finally, gender and hormone influences on muscle function has been assessed in an attempt to understand the strong male predominance in this disorder. Third, we have investigated the influence of sleep on a number of the major controllers of respiration and the relationship between ventilatory control measures and the development of sleep disordered breathing. The combination of studies described above has substantially improved our understanding of the pathogenesis of sleep apnea and other breathing abnormalities during sleep
Trainees
David Slamowitz, MD (1996-1999)
Toshiki Akahoshi, MD (1997-2000)
Robert B. Fogel, MD (1998 -2000)
Atul Malhotra, MD (1998 -2000)
Giora Pillar, MD, PhD (1998-2000)
Yaqi Huang, PhD (1999-2000)
Michael L. Stanchina, MD (2000-2002)
Sanjay R. Patel, MD, MPH (2001-2003)
Kelly A. Carden, MD, MBA (2002-2004)
Amy S. Jordan, PhD (2003-2005)
Raphael Heinzer, MD, MPH (2004-2005)
D. Andrew Wellman, MD (2001 -2007)
Yu-Lun (Allen) Lo, MD (2004-2007)
Pankaj Merchia, MD (2005-2007)
Danny J. Eckert, PhD (2007-present)
Toshiki Akahoshi, MD (1997-2000)
Robert B. Fogel, MD (1998 -2000)
Atul Malhotra, MD (1998 -2000)
Giora Pillar, MD, PhD (1998-2000)
Yaqi Huang, PhD (1999-2000)
Michael L. Stanchina, MD (2000-2002)
Sanjay R. Patel, MD, MPH (2001-2003)
Kelly A. Carden, MD, MBA (2002-2004)
Amy S. Jordan, PhD (2003-2005)
Raphael Heinzer, MD, MPH (2004-2005)
D. Andrew Wellman, MD (2001 -2007)
Yu-Lun (Allen) Lo, MD (2004-2007)
Pankaj Merchia, MD (2005-2007)
Danny J. Eckert, PhD (2007-present)
Research Funding
NIH R01: Phenopyting in Obstructive Sleep Apnea,
SCOR: Harvard Center on the Neurobiology of Sleep and Sleep Apnea
SCOR: Harvard Center on the Neurobiology of Sleep and Sleep Apnea
Selected Publications
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol 2007; 579(Pt 2):515-526. [PMID: 17185342]
Merchia P, Jordan AS, Eckert DJ, Lu A, Schory KE, Malhotra A, White DP. The Influence of Sleep Deprivation on Pharyngeal Muscle Control, American Thoracic Society Annual Meeting, 2007
Pierce R, White D, Malhotra A, Edwards JK, Kleverlaan D, Palmer L, Trinder J. Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea.
Eur Respir J. 2007 Aug;30(2):345-53. Epub 2007 Apr 25. [PMID: 17459896]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol 2007; 581(Pt 1):291-298. [PMID: 17317747]
Eikermann M, Jordan AS, Chamberlin NL, White DP, Gautam S., Wellman DA, Lo Y, and Malhotra A. The Influence of Aging on Upper Airway Collapsibility during Sleep.
Chest, in press.
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikerman M, Schory K,
Dover L, White DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity.
Thorax. 2007 Mar 27; Epub ahead of print. [PMID: 17389755]
Jordan AS, Heinzer R, Lo Y, Schory K, Dover L, Gautam S, Malhotra A, and White DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans. Thorax. 2007 Apr 5; [Epub ahead of print] [PMID: 17412778]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical Control Stability in the Elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea.
Laryngoscope 2007; 117(4):648-653. [PMID: 17415135]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Yang CK, Jordan AS, White DP, Winkelman JW. Heart rate response to respiratory events with or without leg movements.
Sleep. 2006 Apr 1;29(4):553-6.
Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration.
Sleep 2006; 29:881-9. [PMID: 16895254]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between Reduced Sleep and Weight Gain in Women.
Am J Epidemiol 2006; 164(10):947-954. [PMID: 16914506]
Malhotra A, Huang Y, Pillar G, White DP. Aging and Menopausal Influences on Pharyngeal Anatomy and Physiology: The predisposition to Sleep Apnea.
American Journal of Medicine, 2006; 119: 72.e9-72.e14.
Pittman SD, Pillar G, Berry RB, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep Breath 2006; 10(3):123-131. [PMID: 16586136]
Malhotra A, Huang Y, Fogel RB, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J Med 119:72e9-72e14, 2006. [PMID: 16431197]
Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7 [PMID: 15994243 ]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med. 2005 Jul 1;172(1):114-7. [PMID: 15817803]
McGuire M, Zhang Y, White DP, Ling L. Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats.
J. Physiol. (Lond.). 576.2: 599-611,2005. [PMID: 15932891]
Huang Y, Malhotra A, White DP. Computational Simulation of Human Upper Airway Collapse Using a Pressure/State-Dependent Model of Genioglossal Muscle Contraction under Laminar Flow Condition.
Journal of Applied Physiology, 2005; 99 (3): 1138-1148. [PMID: 15831800]
Huang Y, White DP, Malhotra A. The Impact of Anatomical Manipulations on Pharyngeal Collapse: Results from a Computational Model of the Normal Human Upper Airway.
Chest, 2005; 128: 1324-1330.
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol 2005 Sep; 99(3):1138-48. [PMID: 15831800]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnea versus controls.
J Physiol 2005 Apr 15;564(Pt 2):549-62. [PMID: 15695240]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: Results of a meta-analysis.
Sleep 2004; 27: 249-53. [PMID: 15124718]
Patel SR, Palmer LJ, Larkin EK, Jenny NS, White DP, Redline S. Relationship between obstructive sleep apnea and diurnal leptin rhythms.
Sleep 2004; 27: 235-9. [PMID: 15124716]
Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB. A prospective study of sleep duration and mortality risk in women.
Sleep 2004; 27:440-4. [PMID: 15164896]
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004; 27: 1105-12.
Zhang Y, McGuire M, White DP and Ling L. Serotonin receptor subtypes involved in vagus nerve stimulation-induced phrenic long-term facilitation in rats. Neurosci Lett. 2004 Jun 10; 363(2):108-11. [PMID: 15172095]
McGuire M, Zhang Y, White DP and Ling L. Serotonin Receptor Subtypes Required for Ventilatory Long-Term Facilitation and Its Enhancement after Chronic Intermittent Hypoxia in Awake Rats.
Am J Physiol Regul Integr Comp Physiol. 2004; 286(2):R334-41. [PMID: 14551171]
Hedner J, Pillar G, Pittman SD, Zou D, Grote L, White DP. A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients. Sleep 27: 1560-66, 2004. [PMID: 15683148]
Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep 2004 Aug 1;27(5):923-33. [PMID: 15453551]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (London) 2004 Aug 1;558(Pt 3):993-1004. [PMID: 15218069]
Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep 2004 Nov 1;27(7):1394-403. [PMID: 15586793]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep 2004 Mar 15;27(2):249-53. [PMID: 15124718]
Fogel RB, Trinder JH, White DP, Malhotra A, Kleverlaan D, and Pierce RJ. Control of Upper Airway Muscle Activity During Sleep Onset in Patients with Sleep Apnea Versus Controls.
Annual APSS Meeting, Philadelphia, 2004. [PMID: 15695240]
Fogel RB, White DP, Malhotra A, Jordan AS, Kleverlaan D, Wilkinson V, Hutchinson E, and Trinder J. The Cardiopulmonary Response to Arousal is Diminished in Middle-Aged compared with Younger Men.
Annual APSS Meeting, Philadelphia, 2004.
Fogel RB, Malhotra A, White DP. The Pathophysiology of Obstructive Sleep Apnoea.
Thorax; 59:2 170-173. 2004
Wellman A, Jordan AS, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Defining the role of ventilatory instability in obstructive sleep apnea.
Am J Respir Crit Care Med 2003; 167:A791. (Abstract)
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, and White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol 94: 205-212, 2003. [PMID: 12391042]
Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, Patel SR, Hu FB. A prospective study of self-reported sleep duration and incident diabetes in women.
Diabetes Care 2003; 26:380-4. [PMID: 12547866]
Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT. CPAP therapy is effective in treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis. Arch Intern Med 2003; 163:565-71.
Stanchina ML, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. The impact of changing lung volumes on CPAP requirements in OSA patients.
Am J Resp Crit Care Med, 2003.
Zhang Y, McGuire M, White DP, and Ling L. Episodic Phrenic-Inhibitory Vagus Nerve Stimulation Paradoxically Induces Phrenic Long-Term Facilitation in Rats. J Physiol. 2003; 551(3): 981-991. [PMID: 12872010]
McGuire M, Zhang Y, White DP and Ling L. Chronic Intermittent Hypoxia Enhances Ventilatory Long-Term Facilitation in Awake Rats.
J Appl Physiol. 2003; 95:1499-1580. [PMID: 12819226]
Stanchina ML, Malhotra A, White DP. Diagnosis and treatment of respiratory disorders of sleep.
Textbook of Pulmonary Diseases, Crapo, Schwartz, King, Karlinsky editors, 2003.
Fogel RB, Trinder J, Malhotra A, Stanchina ML, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
J Physiol (Lond) 2003; e-pub ahead of print. [PMID: 12807995]
Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
J Appl Physiol 94: 1875-1882, 2003. [PMID: 12533492]
Margel D, White D, Pillar G. Long-term intermittent exposure to high ambient CO2 causes respiratory disturbances during sleep in submariners. Chest 124: 1716-23, 2003. [PMID: 14605040]
Stanchina ML, Malhotra A, Fogel RB, Trinder J, Ayas N, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003 Nov 1;26(7):851-6. [PMID: 14655919]
Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol 2003 Dec 1;553(Pt 2):535-44.
Fogel RB, Malhotra A, Dalagiorgou G, Robinson M, Jakab M, Kikinis R, Pittman SD, White DP. Anatomic and physiologic predictors of apnea severity in morbidly obese subjects.
Sleep 2003 Mar 15;26(2):150-5. [PMID: 12683472]
Ayas N, White DP, Manson J, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women. Arch of Intern Med 2003 Jan 27;163(2):205-9. [PMID: 12546611]
Fogel RB, Pierce RJ, White DP, Malhotra A, Edwards JK, Dunai J, Kleverlaan D, and Trinder J. The Effect of CPAP on Upper Airway Muscle Activation during Sleep Onset in Older vs. Younger Men.
Annual ALA/ATS International Conference, Seattle, 2003 Abstract # C017.
Stanchina ML, Malhotra A, Fogel RB, Millman RP, Edwards JK, Schory K and White DP. The Influence of Lung Volume Changes during sleep on Pharyngeal Mechanics in Obstructive Sleep Apnea (OSA) Patients.
Annual ALA/ATS International Conference, Seattle, 2003 Abstract #.
Pierce RJ, White DP, Trinder J, Edwards JK, Malhotra A, Palmer L, and Fogel RB. Relationships between Upper Airway Anatomy and Dilator Muscle Activation in Obstructive Sleep Apnea.
Annual ALA/ATS International Conference, Seattle, 2003 Abstract # 901.
Malhotra A, Fogel RB, White DP. Disorders of Excessive Sleepiness (DOES). In: Noseworthy J, editor.
Neurological Therapeutics: Principles and Practices, London: Martin Dunitz Publishers; 1306-1309. 2003.
Fogel RB. Review of Sleep Medicine Pearls, 2nd edition by Berry RB. for Sleep. 26: 393. 2003.
Jordan AS, White DP, Fogel RB. Recent Advances in Understanding the Pathogenesis of Obstructive Sleep Apnea.
Current Opinions in Pulmonary Medicine. 9:6 459-464. 2003. [PMID: 14534395]
Wellman A, Malhotra A, White DP. Atrial pacing in sleep apnea syndrome.
New England Journal of Medicine. 347(6):445-446, 2002 Aug 8.
Stanchina ML, Malhotra A, Fogel RB, Ayas NT, Edwards JK, Schory K, White DP. The influence changing lung volume on genioglossus muscle activation and pharyngeal collapsibility during NREM sleep.
American Journal of Respiratory and Critical Care Medicine 2002.
Stanchina ML, Shiels S, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. The influence of passive lung volume changes on upper airway size during wakefulness.
American Journal of Respiratory and Critical Care Medicine 2002.
Ayas NT, Pittman SD, Malhotra A, Pillar G, Stanchina ML, Winkelman J, White DP. Prediction of daytime sleepiness using indices of autonomic arousal.
American Journal of Respiratory and Critical Care Medicine 2002.
Malhotra A, Lazic SE, Fogel RB, Stanchina ML, Ayas N, White DP. Structural and functional differences in the upper airway between premenopausal and postmenopausal women.
American Journal of Respiratory and Critical Care Medicine 2002.
Fogel RB, Trinder JH, Malhotra A, Stanchina ML, Schory K, Edwards JK, White DP. The effect of sleep on genioglossal muscle activation during negative pressure ventilation.
Amercian Journal of Respiratory and Critical Care Medicine 2002.
Malhotra A, Trinder J, Stanchina ML, Fogel RB, Edwards JK, Schory K, White DP. Tonic and Phasic Upper Airway Muscle Reflexes: The influence of posture. American Journal of Respiratory and Critical Care Medicine 2002.
Stanchina ML, Malhotra A, Fogel RB, Ayas NT, Edwards JK, Schory K, White DP. The influence of lung volume changes on genioglossus muscle activation and upper airway collapsibility during sleep.
Sleep 2002
McGuire M, Zhang Y, White DP and Ling L. Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats J. Appl. Physiol. 2002, 93(6): 2155-2161.
Stanchina ML, Malhotra A, Fogel RB, Ayas N, Edwards JK, Shory K, White DP, Upper airway muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir and Crit Care Medicine 2002; 165: 945-949.
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring S, White DP. The Male Gender Predisposition to Obstructive Sleep Apnea: Importance of Airway Length.
American Journal of Respiratory and Critical Care Medicine 2002; 166: 1388-1395.
Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D, White DP. Pharyngeal pressure and flow efects on genioglossus activation in normal subjects.
Am J Resp Crit Care Med 165: 71-77, 2002.
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP. The Male predisposition to pharyngeal collapse: Importance of airway length.
Am J Resp Crit Care Med 166: 1388-95, 2002.
Stanchina M, Malhotra A, Fogel R, Edwards JK, Schory K, Ayas N, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir Crit Care Med 2002 Apr 1;165(7):945-9.
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, Ayas N, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med 2002;Jan 1;165(1):71-7.
Malhotra A, Fogel RB, Wellman DA, Stanchina ML, Jordan A, Schory K, Pillar G, and White DP. State Dependence of Gender Differences in Upper Airway Reflexes. Annual ALA/ATS International Conference, Seattle, 2002 Abstract #
Wellman DA, Malhotra A, Fogel RB, Edwards JK, Schory K, and White DP. Gender Influences on Respiratory Loop Gain.
Annual ALA/ATS International Conference, Atlanta, 2002 Abstract #
Stanchina ML, Malhotra A, Fogel R, Edwards J, Ayas N, White DP. Genioglossus muscle responsiveness to resistive loading and hypercarbia during NREM sleep.
American Journal of Respiratory and Critical Care Medicine. 2001; 163: A181.
Stanchina ML, Malhotra A, Fogel RB, Edwards JK, Ayas N, White DP. Upper airway responsiveness to hypercapnea, hypoxemia and resistive loading during NREM sleep.
Sleep 2001; 24: A271.
Pillar G, Malhotra A, Fogel RB, Stanchina ML, Edwards J, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
American Journal of Respiratory and Critical Care Medicine. 2001; 163: A181.
Malhotra A, Schwartz DR, Ayas N, Stanchina ML, White DP. Five mechanisms of hyperoxic hypercarbia [letter].
Lancet. 357 (9259) 884-5, 2001.
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endocrinol Metab, 86: 1175-80, 2001.
Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, White DP. Upper airway collapsibility: measurements and sleep effects.
Chest 120: 156-61, 2001.
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med 2001;164:2025-30.
Fogel RB, Malhotra A, Pillar G, Dalgiorgou G, Pittman S, Jakab M, Robinson M, White DP. The Effect of Surgically Induced Weight Loss on Sleep-Disordered Breathing and Pharyngeal Anatomy.
Annual APSS International Conference, Chicago, 2001.
Fogel RB, Malhotra A, Dalagiorgiou G, Pittman SP, Jakab M, Robinson MW, White DP. Anatomical and Physiological Predictors of Apnea Severity in Morbidly Obese Subjects. Annual ALA/ATS International Conference, San Francisco.
2001 Am J Resp Crit Care Med. 164: A835.4.
Malhotra A, Pillar G, Fogel RB, Ayas N, Edwards J, White DP. Influence of Pressure versus Flow on Genioglossus Activation During Passive Mechanical Ventilation. Annual ALA/ATS International Conference, San Francisco.
2001 Am J Resp Crit Care Med. 164: A181.
Huang Y, Malhotra A, Fogel RB, Kikinis R, White DP. A Finite Element Analysis of Gender Differences in Upper Airway Structure. Annual ALA/ATS International Conference, San Francisco, 2001.
Am J Resp Crit Care Med. 164: A635.
Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal Inspiratory Activation: Central Respiratory versus Mechanoreceptive Influences.
Resp Physiol. 127: 23-38. 2001.
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased Prevalence of Obstructive Sleep Apnea in Obese Women with Polycystic Ovary Syndrome.
J. Clin Endocrin Metab. 86:3 1175-1180 2001.
Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, Slamowitz DI, Shea, SA, White DP. Genioglossus but not palatal muscle activity relates closely to pharyngeal pressure.
Am J Resp Crit Care Med, 162:1058-1062, 2000.
Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO2 during non-REM sleep.
J Appl Physiol, 89:1275-82, 2000.
Pillar G, Malhotra A, Fogel RB, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: Influence of gender.
Am J Resp Crit Care Med, 162:1627-32, 2000.
Pittman SD, Tal N, Pillar G, Malhotra A, Hilton M, Fogel R, Ayas N, White DP. Automated detection of obstructive sleep-disordered breathing events using peripheral arterial tonometry and oximetry.
Computers in Cardiology 27:485-488, 2000.
Malhotra A, Fogel R, Edwards J, Shea S, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000;161:1746-9.
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000;162:1058-62.
Pillar G, Malhotra A, Edwards J, Beauregard J Fogel R, Shea S White DP. Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.
J Appl Phys 2000;89:1275-82.
Fogel RB, White DP. Obstructive Sleep Apnea. In: Schrier R, editor.
Advances in Internal Medicine, Vol 45. St. Louis: Mosby Yearbook Publishing; 2000.
Pittman SD, Hill PD, Malhotra A, Fogel RB, Stevenson LW, Ravid S, White DP. Stabilizing Cheyne-Stokes Respiration Associated with Congestive Heart Failure Using Computer-Assisted Positive Airway Pressure.
Computers in Cardiology. 27: 201-204 2000.
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced Genioglossal Activity Following Upper Airway Anesthesia in Patients with Obstructive Sleep Apnea.
J Appl Physiol. 88:4 1346-1354 2000.
Fogel RB, Malhotra A, Pillar G, Pittman S, Beauregard J, Edwards JK, Robinson M, and White DP. The effects of Surgically Induced Weight Loss on Sleep Disordered Breathing and Pharyngeal Muscle Function, 1999.
Pillar G, Malhotra A, Fogel RB, Beauregard J, and White DP. Increased Upper Airway Collapsibility and Decreased Ventilation in Men vs Women in Response to Resistive Loading during NREM Sleep, 1999.
J Physiol 2007; 579(Pt 2):515-526. [PMID: 17185342]
Merchia P, Jordan AS, Eckert DJ, Lu A, Schory KE, Malhotra A, White DP. The Influence of Sleep Deprivation on Pharyngeal Muscle Control, American Thoracic Society Annual Meeting, 2007
Pierce R, White D, Malhotra A, Edwards JK, Kleverlaan D, Palmer L, Trinder J. Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea.
Eur Respir J. 2007 Aug;30(2):345-53. Epub 2007 Apr 25. [PMID: 17459896]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol 2007; 581(Pt 1):291-298. [PMID: 17317747]
Eikermann M, Jordan AS, Chamberlin NL, White DP, Gautam S., Wellman DA, Lo Y, and Malhotra A. The Influence of Aging on Upper Airway Collapsibility during Sleep.
Chest, in press.
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikerman M, Schory K,
Dover L, White DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity.
Thorax. 2007 Mar 27; Epub ahead of print. [PMID: 17389755]
Jordan AS, Heinzer R, Lo Y, Schory K, Dover L, Gautam S, Malhotra A, and White DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans. Thorax. 2007 Apr 5; [Epub ahead of print] [PMID: 17412778]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical Control Stability in the Elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea.
Laryngoscope 2007; 117(4):648-653. [PMID: 17415135]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Yang CK, Jordan AS, White DP, Winkelman JW. Heart rate response to respiratory events with or without leg movements.
Sleep. 2006 Apr 1;29(4):553-6.
Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration.
Sleep 2006; 29:881-9. [PMID: 16895254]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between Reduced Sleep and Weight Gain in Women.
Am J Epidemiol 2006; 164(10):947-954. [PMID: 16914506]
Malhotra A, Huang Y, Pillar G, White DP. Aging and Menopausal Influences on Pharyngeal Anatomy and Physiology: The predisposition to Sleep Apnea.
American Journal of Medicine, 2006; 119: 72.e9-72.e14.
Pittman SD, Pillar G, Berry RB, Malhotra A, MacDonald MM, White DP. Follow-up assessment of CPAP efficacy in patients with obstructive sleep apnea using an ambulatory device based on peripheral arterial tonometry.
Sleep Breath 2006; 10(3):123-131. [PMID: 16586136]
Malhotra A, Huang Y, Fogel RB, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J Med 119:72e9-72e14, 2006. [PMID: 16431197]
Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7 [PMID: 15994243 ]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med. 2005 Jul 1;172(1):114-7. [PMID: 15817803]
McGuire M, Zhang Y, White DP, Ling L. Phrenic long-term facilitation requires NMDA receptors in the phrenic motonucleus in rats.
J. Physiol. (Lond.). 576.2: 599-611,2005. [PMID: 15932891]
Huang Y, Malhotra A, White DP. Computational Simulation of Human Upper Airway Collapse Using a Pressure/State-Dependent Model of Genioglossal Muscle Contraction under Laminar Flow Condition.
Journal of Applied Physiology, 2005; 99 (3): 1138-1148. [PMID: 15831800]
Huang Y, White DP, Malhotra A. The Impact of Anatomical Manipulations on Pharyngeal Collapse: Results from a Computational Model of the Normal Human Upper Airway.
Chest, 2005; 128: 1324-1330.
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol 2005 Sep; 99(3):1138-48. [PMID: 15831800]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnea versus controls.
J Physiol 2005 Apr 15;564(Pt 2):549-62. [PMID: 15695240]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: Results of a meta-analysis.
Sleep 2004; 27: 249-53. [PMID: 15124718]
Patel SR, Palmer LJ, Larkin EK, Jenny NS, White DP, Redline S. Relationship between obstructive sleep apnea and diurnal leptin rhythms.
Sleep 2004; 27: 235-9. [PMID: 15124716]
Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB. A prospective study of sleep duration and mortality risk in women.
Sleep 2004; 27:440-4. [PMID: 15164896]
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004; 27: 1105-12.
Zhang Y, McGuire M, White DP and Ling L. Serotonin receptor subtypes involved in vagus nerve stimulation-induced phrenic long-term facilitation in rats. Neurosci Lett. 2004 Jun 10; 363(2):108-11. [PMID: 15172095]
McGuire M, Zhang Y, White DP and Ling L. Serotonin Receptor Subtypes Required for Ventilatory Long-Term Facilitation and Its Enhancement after Chronic Intermittent Hypoxia in Awake Rats.
Am J Physiol Regul Integr Comp Physiol. 2004; 286(2):R334-41. [PMID: 14551171]
Hedner J, Pillar G, Pittman SD, Zou D, Grote L, White DP. A novel adaptive wrist actigraphy algorithm for sleep-wake assessment in sleep apnea patients. Sleep 27: 1560-66, 2004. [PMID: 15683148]
Pittman SD, Ayas NT, MacDonald MM, Malhotra A, Fogel RB, White DP. Using a wrist-worn device based on peripheral arterial tonometry to diagnose obstructive sleep apnea: in-laboratory and ambulatory validation.
Sleep 2004 Aug 1;27(5):923-33. [PMID: 15453551]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (London) 2004 Aug 1;558(Pt 3):993-1004. [PMID: 15218069]
Pittman SD, MacDonald MM, Fogel RB, Malhotra A, Todros K, Levy B, Geva AB, White DP. Assessment of automated scoring of polysomnographic recordings in a population with suspected sleep-disordered breathing.
Sleep 2004 Nov 1;27(7):1394-403. [PMID: 15586793]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep 2004 Mar 15;27(2):249-53. [PMID: 15124718]
Fogel RB, Trinder JH, White DP, Malhotra A, Kleverlaan D, and Pierce RJ. Control of Upper Airway Muscle Activity During Sleep Onset in Patients with Sleep Apnea Versus Controls.
Annual APSS Meeting, Philadelphia, 2004. [PMID: 15695240]
Fogel RB, White DP, Malhotra A, Jordan AS, Kleverlaan D, Wilkinson V, Hutchinson E, and Trinder J. The Cardiopulmonary Response to Arousal is Diminished in Middle-Aged compared with Younger Men.
Annual APSS Meeting, Philadelphia, 2004.
Fogel RB, Malhotra A, White DP. The Pathophysiology of Obstructive Sleep Apnoea.
Thorax; 59:2 170-173. 2004
Wellman A, Jordan AS, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. Defining the role of ventilatory instability in obstructive sleep apnea.
Am J Respir Crit Care Med 2003; 167:A791. (Abstract)
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, and White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol 94: 205-212, 2003. [PMID: 12391042]
Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, Patel SR, Hu FB. A prospective study of self-reported sleep duration and incident diabetes in women.
Diabetes Care 2003; 26:380-4. [PMID: 12547866]
Patel SR, White DP, Malhotra A, Stanchina ML, Ayas NT. CPAP therapy is effective in treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis. Arch Intern Med 2003; 163:565-71.
Stanchina ML, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. The impact of changing lung volumes on CPAP requirements in OSA patients.
Am J Resp Crit Care Med, 2003.
Zhang Y, McGuire M, White DP, and Ling L. Episodic Phrenic-Inhibitory Vagus Nerve Stimulation Paradoxically Induces Phrenic Long-Term Facilitation in Rats. J Physiol. 2003; 551(3): 981-991. [PMID: 12872010]
McGuire M, Zhang Y, White DP and Ling L. Chronic Intermittent Hypoxia Enhances Ventilatory Long-Term Facilitation in Awake Rats.
J Appl Physiol. 2003; 95:1499-1580. [PMID: 12819226]
Stanchina ML, Malhotra A, White DP. Diagnosis and treatment of respiratory disorders of sleep.
Textbook of Pulmonary Diseases, Crapo, Schwartz, King, Karlinsky editors, 2003.
Fogel RB, Trinder J, Malhotra A, Stanchina ML, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
J Physiol (Lond) 2003; e-pub ahead of print. [PMID: 12807995]
Berry RB, White DP, Roper J, Pillar G, Fogel RB, Stanchina M, Malhotra A. Awake negative pressure reflex response of the genioglossus in OSA patients and normal subjects.
J Appl Physiol 94: 1875-1882, 2003. [PMID: 12533492]
Margel D, White D, Pillar G. Long-term intermittent exposure to high ambient CO2 causes respiratory disturbances during sleep in submariners. Chest 124: 1716-23, 2003. [PMID: 14605040]
Stanchina ML, Malhotra A, Fogel RB, Trinder J, Ayas N, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003 Nov 1;26(7):851-6. [PMID: 14655919]
Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol 2003 Dec 1;553(Pt 2):535-44.
Fogel RB, Malhotra A, Dalagiorgou G, Robinson M, Jakab M, Kikinis R, Pittman SD, White DP. Anatomic and physiologic predictors of apnea severity in morbidly obese subjects.
Sleep 2003 Mar 15;26(2):150-5. [PMID: 12683472]
Ayas N, White DP, Manson J, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women. Arch of Intern Med 2003 Jan 27;163(2):205-9. [PMID: 12546611]
Fogel RB, Pierce RJ, White DP, Malhotra A, Edwards JK, Dunai J, Kleverlaan D, and Trinder J. The Effect of CPAP on Upper Airway Muscle Activation during Sleep Onset in Older vs. Younger Men.
Annual ALA/ATS International Conference, Seattle, 2003 Abstract # C017.
Stanchina ML, Malhotra A, Fogel RB, Millman RP, Edwards JK, Schory K and White DP. The Influence of Lung Volume Changes during sleep on Pharyngeal Mechanics in Obstructive Sleep Apnea (OSA) Patients.
Annual ALA/ATS International Conference, Seattle, 2003 Abstract #.
Pierce RJ, White DP, Trinder J, Edwards JK, Malhotra A, Palmer L, and Fogel RB. Relationships between Upper Airway Anatomy and Dilator Muscle Activation in Obstructive Sleep Apnea.
Annual ALA/ATS International Conference, Seattle, 2003 Abstract # 901.
Malhotra A, Fogel RB, White DP. Disorders of Excessive Sleepiness (DOES). In: Noseworthy J, editor.
Neurological Therapeutics: Principles and Practices, London: Martin Dunitz Publishers; 1306-1309. 2003.
Fogel RB. Review of Sleep Medicine Pearls, 2nd edition by Berry RB. for Sleep. 26: 393. 2003.
Jordan AS, White DP, Fogel RB. Recent Advances in Understanding the Pathogenesis of Obstructive Sleep Apnea.
Current Opinions in Pulmonary Medicine. 9:6 459-464. 2003. [PMID: 14534395]
Wellman A, Malhotra A, White DP. Atrial pacing in sleep apnea syndrome.
New England Journal of Medicine. 347(6):445-446, 2002 Aug 8.
Stanchina ML, Malhotra A, Fogel RB, Ayas NT, Edwards JK, Schory K, White DP. The influence changing lung volume on genioglossus muscle activation and pharyngeal collapsibility during NREM sleep.
American Journal of Respiratory and Critical Care Medicine 2002.
Stanchina ML, Shiels S, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. The influence of passive lung volume changes on upper airway size during wakefulness.
American Journal of Respiratory and Critical Care Medicine 2002.
Ayas NT, Pittman SD, Malhotra A, Pillar G, Stanchina ML, Winkelman J, White DP. Prediction of daytime sleepiness using indices of autonomic arousal.
American Journal of Respiratory and Critical Care Medicine 2002.
Malhotra A, Lazic SE, Fogel RB, Stanchina ML, Ayas N, White DP. Structural and functional differences in the upper airway between premenopausal and postmenopausal women.
American Journal of Respiratory and Critical Care Medicine 2002.
Fogel RB, Trinder JH, Malhotra A, Stanchina ML, Schory K, Edwards JK, White DP. The effect of sleep on genioglossal muscle activation during negative pressure ventilation.
Amercian Journal of Respiratory and Critical Care Medicine 2002.
Malhotra A, Trinder J, Stanchina ML, Fogel RB, Edwards JK, Schory K, White DP. Tonic and Phasic Upper Airway Muscle Reflexes: The influence of posture. American Journal of Respiratory and Critical Care Medicine 2002.
Stanchina ML, Malhotra A, Fogel RB, Ayas NT, Edwards JK, Schory K, White DP. The influence of lung volume changes on genioglossus muscle activation and upper airway collapsibility during sleep.
Sleep 2002
McGuire M, Zhang Y, White DP and Ling L. Effect of hypoxic episode number and severity on ventilatory long-term facilitation in awake rats J. Appl. Physiol. 2002, 93(6): 2155-2161.
Stanchina ML, Malhotra A, Fogel RB, Ayas N, Edwards JK, Shory K, White DP, Upper airway muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir and Crit Care Medicine 2002; 165: 945-949.
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring S, White DP. The Male Gender Predisposition to Obstructive Sleep Apnea: Importance of Airway Length.
American Journal of Respiratory and Critical Care Medicine 2002; 166: 1388-1395.
Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D, White DP. Pharyngeal pressure and flow efects on genioglossus activation in normal subjects.
Am J Resp Crit Care Med 165: 71-77, 2002.
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP. The Male predisposition to pharyngeal collapse: Importance of airway length.
Am J Resp Crit Care Med 166: 1388-95, 2002.
Stanchina M, Malhotra A, Fogel R, Edwards JK, Schory K, Ayas N, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir Crit Care Med 2002 Apr 1;165(7):945-9.
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, Ayas N, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med 2002;Jan 1;165(1):71-7.
Malhotra A, Fogel RB, Wellman DA, Stanchina ML, Jordan A, Schory K, Pillar G, and White DP. State Dependence of Gender Differences in Upper Airway Reflexes. Annual ALA/ATS International Conference, Seattle, 2002 Abstract #
Wellman DA, Malhotra A, Fogel RB, Edwards JK, Schory K, and White DP. Gender Influences on Respiratory Loop Gain.
Annual ALA/ATS International Conference, Atlanta, 2002 Abstract #
Stanchina ML, Malhotra A, Fogel R, Edwards J, Ayas N, White DP. Genioglossus muscle responsiveness to resistive loading and hypercarbia during NREM sleep.
American Journal of Respiratory and Critical Care Medicine. 2001; 163: A181.
Stanchina ML, Malhotra A, Fogel RB, Edwards JK, Ayas N, White DP. Upper airway responsiveness to hypercapnea, hypoxemia and resistive loading during NREM sleep.
Sleep 2001; 24: A271.
Pillar G, Malhotra A, Fogel RB, Stanchina ML, Edwards J, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
American Journal of Respiratory and Critical Care Medicine. 2001; 163: A181.
Malhotra A, Schwartz DR, Ayas N, Stanchina ML, White DP. Five mechanisms of hyperoxic hypercarbia [letter].
Lancet. 357 (9259) 884-5, 2001.
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endocrinol Metab, 86: 1175-80, 2001.
Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, White DP. Upper airway collapsibility: measurements and sleep effects.
Chest 120: 156-61, 2001.
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med 2001;164:2025-30.
Fogel RB, Malhotra A, Pillar G, Dalgiorgou G, Pittman S, Jakab M, Robinson M, White DP. The Effect of Surgically Induced Weight Loss on Sleep-Disordered Breathing and Pharyngeal Anatomy.
Annual APSS International Conference, Chicago, 2001.
Fogel RB, Malhotra A, Dalagiorgiou G, Pittman SP, Jakab M, Robinson MW, White DP. Anatomical and Physiological Predictors of Apnea Severity in Morbidly Obese Subjects. Annual ALA/ATS International Conference, San Francisco.
2001 Am J Resp Crit Care Med. 164: A835.4.
Malhotra A, Pillar G, Fogel RB, Ayas N, Edwards J, White DP. Influence of Pressure versus Flow on Genioglossus Activation During Passive Mechanical Ventilation. Annual ALA/ATS International Conference, San Francisco.
2001 Am J Resp Crit Care Med. 164: A181.
Huang Y, Malhotra A, Fogel RB, Kikinis R, White DP. A Finite Element Analysis of Gender Differences in Upper Airway Structure. Annual ALA/ATS International Conference, San Francisco, 2001.
Am J Resp Crit Care Med. 164: A635.
Pillar G, Fogel RB, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal Inspiratory Activation: Central Respiratory versus Mechanoreceptive Influences.
Resp Physiol. 127: 23-38. 2001.
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased Prevalence of Obstructive Sleep Apnea in Obese Women with Polycystic Ovary Syndrome.
J. Clin Endocrin Metab. 86:3 1175-1180 2001.
Malhotra A, Pillar G, Fogel RB, Beauregard J, Edwards JK, Slamowitz DI, Shea, SA, White DP. Genioglossus but not palatal muscle activity relates closely to pharyngeal pressure.
Am J Resp Crit Care Med, 162:1058-1062, 2000.
Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO2 during non-REM sleep.
J Appl Physiol, 89:1275-82, 2000.
Pillar G, Malhotra A, Fogel RB, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: Influence of gender.
Am J Resp Crit Care Med, 162:1627-32, 2000.
Pittman SD, Tal N, Pillar G, Malhotra A, Hilton M, Fogel R, Ayas N, White DP. Automated detection of obstructive sleep-disordered breathing events using peripheral arterial tonometry and oximetry.
Computers in Cardiology 27:485-488, 2000.
Malhotra A, Fogel R, Edwards J, Shea S, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000;161:1746-9.
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000;162:1058-62.
Pillar G, Malhotra A, Edwards J, Beauregard J Fogel R, Shea S White DP. Upper airway muscle responsiveness to rising PCO2 during NREM Sleep.
J Appl Phys 2000;89:1275-82.
Fogel RB, White DP. Obstructive Sleep Apnea. In: Schrier R, editor.
Advances in Internal Medicine, Vol 45. St. Louis: Mosby Yearbook Publishing; 2000.
Pittman SD, Hill PD, Malhotra A, Fogel RB, Stevenson LW, Ravid S, White DP. Stabilizing Cheyne-Stokes Respiration Associated with Congestive Heart Failure Using Computer-Assisted Positive Airway Pressure.
Computers in Cardiology. 27: 201-204 2000.
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced Genioglossal Activity Following Upper Airway Anesthesia in Patients with Obstructive Sleep Apnea.
J Appl Physiol. 88:4 1346-1354 2000.
Fogel RB, Malhotra A, Pillar G, Pittman S, Beauregard J, Edwards JK, Robinson M, and White DP. The effects of Surgically Induced Weight Loss on Sleep Disordered Breathing and Pharyngeal Muscle Function, 1999.
Pillar G, Malhotra A, Fogel RB, Beauregard J, and White DP. Increased Upper Airway Collapsibility and Decreased Ventilation in Men vs Women in Response to Resistive Loading during NREM Sleep, 1999.
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