Division of Sleep Medicine @ Harvard Medical School
Faculty Profile
David P. White, MD
Clinical Professor of Sleep Medicine, Harvard Medical School
Senior Physician, Division of Sleep Medicine, Department of Medicine, Brigham and Women's Hospital
Other Affiliation(s)
Chief Medical Officer: Philips Respironics
Society Memberships
American Academy of Sleep MedicineAmerican Thoracic Society
American College of Chest Physicians
American Society for Clinical Investigation
American Association of Physicians
Research Unit(s)
Sleep Disorders Program, Division of Sleep Medicine, Brigham and Women's Hospital
Research Interests
The research in my laboratory primarily addresses understanding the pathophysiology of obstructive sleep apnea and other disorders of breathing during sleep. In approaching this disorder there are three principal areas of investigation: 1) airway anatomy, 2) upper airway muscle control, and 3) the general control of breathing. First, regarding upper airway anatomy, we have previously and are currently studying the airway using MRI and CT methodologies with a particular focus on the influence of aging, obesity and androgens on pharyngeal anatomy. We have also developed a computational (finite element) model of the human upper airway to aid in understanding physiology and to develop new therapies. Second, motor control of the upper airway has been the principal focus of my laboratory for at least the last 10 years. We have defined the normal activation pattern and function of a number of pharyngeal muscles and subsequently determined the influence of state (sleep) on these muscles. Muscle performance in patients with sleep apnea has also been compared to normal controls in defining the pathophysiology of airway collapse during sleep. How these muscles respond to standard respiratory stimuli (chemistry, negative pressure) has also been defined awake and asleep. Finally, gender and hormone influences on muscle function has been assessed in an attempt to understand the strong male predominance in this disorder. Third, we have investigated the influence of sleep on a number of the major controllers of respiration and the relationship between ventilatory control measures and the development of sleep disordered breathing. The combination of studies described above has substantially improved our understanding of the pathogenesis of sleep apnea and other breathing abnormalities during sleep
Trainees
David Slamowitz, MD (1996-1999)
Toshiki Akahoshi, MD (1997-2000)
Robert B. Fogel, MD (1998 -2000)
Atul Malhotra, MD (1998 -2000)
Giora Pillar, MD, PhD (1998-2000)
Yaqi Huang, PhD (1999-2000)
Michael L. Stanchina, MD (2000-2002)
Sanjay R. Patel, MD, MPH (2001-2003)
Kelly A. Carden, MD, MBA (2002-2004)
Amy S. Jordan, PhD (2003-2005)
Raphael Heinzer, MD, MPH (2004-2005)
D. Andrew Wellman, MD (2001 -2007)
Yu-Lun (Allen) Lo, MD (2004-2007)
Pankaj Merchia, MD (2005-2007)
Danny J. Eckert, PhD (2007-present)
Toshiki Akahoshi, MD (1997-2000)
Robert B. Fogel, MD (1998 -2000)
Atul Malhotra, MD (1998 -2000)
Giora Pillar, MD, PhD (1998-2000)
Yaqi Huang, PhD (1999-2000)
Michael L. Stanchina, MD (2000-2002)
Sanjay R. Patel, MD, MPH (2001-2003)
Kelly A. Carden, MD, MBA (2002-2004)
Amy S. Jordan, PhD (2003-2005)
Raphael Heinzer, MD, MPH (2004-2005)
D. Andrew Wellman, MD (2001 -2007)
Yu-Lun (Allen) Lo, MD (2004-2007)
Pankaj Merchia, MD (2005-2007)
Danny J. Eckert, PhD (2007-present)
Mentor(s)
John Weil, MD
Clifford Zwillicj, MD
Clifford Zwillicj, MD
Research Funding
NIH R01: Phenopyting in Obstructive Sleep Apnea,
SCOR: Harvard Center on the Neurobiology of Sleep and Sleep Apnea
SCOR: Harvard Center on the Neurobiology of Sleep and Sleep Apnea
Selected Publications
White DP. Opioid-induced suppression of genioglossal muscle activity: is it clinically important? J Physiol. 2009 Jul 15;587(Pt 14):3421-2. [PMID:19602634]
Joffe H, Soares CN, Thurston RC, White DP, Cohen LS, Hall JE. Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptoms.
Menopause. 2009 Jul-Aug;16(4):671-9. [PMID: 19197217]
Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
Chest. 2009 Apr;135(4):957-64. Epub 2008 Dec 31. [PMID:19118266]
Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep. 2009 Mar 1;32(3):361-8. [PMID: 19294956]
McGuire M, Tartar JL, Cao Y, McCarley RW, White DP, Strecker RE, Ling L. Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors.
J Physiol. 2008 Nov 1;586(Pt 21):5215-29. [PMID: 18787037]
Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S,
Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T; American
Heart Association Council for High Blood Pressure Research Professional Education
Committee, Council on Clinical Cardiology; American Heart Association Stroke
Council; American Heart Association Council on Cardiovascular Nursing; American College of Cardiology Foundation. Sleep apnea and cardiovascular disease: an American Heart Association/American College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education
Committee, Council on Clinical Cardiology, Stroke Council, and Council On
Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood
Institute National Center on Sleep Disorders Research (National Institutes of
Health).
Circulation. 2008 Sep 2;118(10):1080-111. [PMID: 18725495]
Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP. Effect of oxygen in obstructive sleep apnea: role of loop gain.
Respir Physiol Neurobiol. 2008 Jul 31;162(2):144-51. [PMID: 18577470]
Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during sleep onset.
Sleep. 2008 Apr 1;31(4):525-33. [PMID: 18457240]
Saboisky JP, Butler JE, McKenzie DK, Gorman RB, Trinder JA, White DP, Gandevia SC. Neural drive to human genioglossus in obstructive sleep apnoea.
J Physiol. 2007 Nov 15;585(Pt 1):135-46. [PMID: 17916615]
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol 2007; 579(Pt 2):515-526. [PMID: 17185342]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol 2007; 581(Pt 1):291-298. [PMID: 17317747]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikerman M, Schory K, Dover L, White DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity.
Thorax. 2007 Mar 27; Epub ahead of print. [PMID: 17389755]
Jordan AS, Heinzer R, Lo Y, Schory K, Dover L, Gautam S, Malhotra A, and White DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans.
Thorax. 2007 Apr 5; [Epub ahead of print] [PMID: 17412778]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical Control Stability in the Elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration.
Sleep 2006; 29:881-9. [PMID: 16895254]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between Reduced Sleep and Weight Gain in Women.
Am J Epidemiol 2006; 164(10):947-954. [PMID: 16914506]
Malhotra A, Huang Y, Pillar G, White DP. Aging and Menopausal Influences on Pharyngeal Anatomy and Physiology: The predisposition to Sleep Apnea.
American Journal of Medicine, 2006; 119: 72.e9-72.e14.
Malhotra A, Huang Y, Fogel RB, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J Med 119:72e9-72e14, 2006. [PMID: 16431197]
Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7 [PMID: 15994243 ]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med. 2005 Jul 1;172(1):114-7. [PMID: 15817803]
Huang Y, Malhotra A, White DP. Computational Simulation of Human Upper Airway Collapse Using a Pressure/State-Dependent Model of Genioglossal Muscle Contraction under Laminar Flow Condition.
Journal of Applied Physiology, 2005; 99 (3): 1138-1148. [PMID: 15831800]
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol 2005 Sep; 99(3):1138-48. [PMID: 15831800]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnea versus controls.
J Physiol 2005 Apr 15;564(Pt 2):549-62. [PMID: 15695240]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: Results of a meta-analysis.
Sleep 2004; 27: 249-53. [PMID: 15124718]
Patel SR, Palmer LJ, Larkin EK, Jenny NS, White DP, Redline S. Relationship between obstructive sleep apnea and diurnal leptin rhythms.
Sleep 2004; 27: 235-9. [PMID: 15124716]
Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB. A prospective study of sleep duration and mortality risk in women.
Sleep 2004; 27:440-4. [PMID: 15164896]
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004; 27: 1105-12. [PMID: 15532204]
McGuire M, Zhang Y, White DP and Ling L. Serotonin Receptor Subtypes Required for Ventilatory Long-Term Facilitation and Its Enhancement after Chronic Intermittent Hypoxia in Awake Rats.
Am J Physiol Regul Integr Comp Physiol. 2004; 286(2):R334-41. [PMID: 14551171]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (London) 2004 Aug 1;558(Pt 3):993-1004. [PMID: 15218069]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep 2004 Mar 15;27(2):249-53. [PMID: 15124718]
Fogel RB, Trinder JH, White DP, Malhotra A, Kleverlaan D, and Pierce RJ. Control of Upper Airway Muscle Activity During Sleep Onset in Patients with Sleep Apnea Versus Controls.
Annual APSS Meeting, Philadelphia, 2004. [PMID: 15695240]
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, and White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol 94: 205-212, 2003. [PMID: 12391042]
Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, Patel SR, Hu FB. A prospective study of self-reported sleep duration and incident diabetes in women.
Diabetes Care 2003; 26:380-4. [PMID: 12547866]
Patel SR, White DP, Malhotra, A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Arch Intern Med 2003, 163:565-71. [PMID: 12622603]
Stanchina ML, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. The impact of changing lung volumes on CPAP requirements in OSA patients.
Am J Resp Crit Care Med, 2003.
Fogel RB, Trinder J, Malhotra A, Stanchina ML, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
J Physiol (Lond) 2003; e-pub ahead of print. [PMID: 12807995]
Stanchina ML, Malhotra A, Fogel RB, Trinder J, Ayas N, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003 Nov 1;26(7):851-6. [PMID: 14655919]
Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol 2003 Dec 1;553(Pt 2):535-44. [PMID: 12963804]
Ayas N, White DP, Manson J, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women. Arch of Intern Med 2003 Jan 27;163(2):205-9. [PMID: 12546611]
Stanchina M, Malhotra A, Fogel R, Ayas, N, Edwards JK, Schory K, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during non-rapid eye movement sleep.
Am J Respir Crit Care Med 2002, 165:945-9. [PMID: 11934719]
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring S, White DP. The Male Gender Predisposition to Obstructive Sleep Apnea: Importance of Airway Length.
American Journal of Respiratory and Critical Care Medicine 2002; 166: 1388-1395. [PMID: 12421747]
Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D, White DP. Pharyngeal pressure and flow efects on genioglossus activation in normal subjects.
Am J Resp Crit Care Med 165: 71-77, 2002. [PMID: 11779733]
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP. The Male predisposition to pharyngeal collapse: Importance of airway length.
Am J Resp Crit Care Med 166: 1388-95, 2002. [PMID: 12421747]
Stanchina M, Malhotra A, Fogel R, Edwards JK, Schory K, Ayas N, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir Crit Care Med 2002 Apr 1;165(7):945-9. [PMID: 11934719]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, Ayas N, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med 2002;Jan 1;165(1):71-7. [PMID: 11779733]
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endocrinol Metab, 86: 1175-80, 2001. [PMID: 11238505]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med 2001, 164:2025-30. [PMID: 11739130]
Pillar G, Fogel R, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
Respir Physiol 2001, 127:23-38. [PMID: 11445198]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000;162:1058-62. [PMID: 10988130]
Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO2 during non-REM sleep.
J Appl Physiol, 89:1275-82, 2000. [PMID: 11007559]
Pillar G, Malhotra A, Fogel RB, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: Influence of gender.
Am J Resp Crit Care Med, 162:1627-32, 2000. [PMID: 11069787]
Malhotra A, Fogel R, Edwards J, Shea S, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000;161:1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol 2000;88:1346-54. [PMID: 10749829]
Book Chapters
Stanchina ML, Malhotra A, White DP. Diagnosis and treatment of respiratory disorders of sleep.
Textbook of Pulmonary Diseases, Crapo, Schwartz, King, Karlinsky editors, 2003.
Joffe H, Soares CN, Thurston RC, White DP, Cohen LS, Hall JE. Depression is associated with worse objectively and subjectively measured sleep, but not more frequent awakenings, in women with vasomotor symptoms.
Menopause. 2009 Jul-Aug;16(4):671-9. [PMID: 19197217]
Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep.
Chest. 2009 Apr;135(4):957-64. Epub 2008 Dec 31. [PMID:19118266]
Jordan AS, White DP, Lo YL, Wellman A, Eckert DJ, Yim-Yeh S, Eikermann M, Smith SA, Stevenson KE, Malhotra A. Airway dilator muscle activity and lung volume during stable breathing in obstructive sleep apnea.
Sleep. 2009 Mar 1;32(3):361-8. [PMID: 19294956]
McGuire M, Tartar JL, Cao Y, McCarley RW, White DP, Strecker RE, Ling L. Sleep fragmentation impairs ventilatory long-term facilitation via adenosine A1 receptors.
J Physiol. 2008 Nov 1;586(Pt 21):5215-29. [PMID: 18787037]
Somers VK, White DP, Amin R, Abraham WT, Costa F, Culebras A, Daniels S,
Floras JS, Hunt CE, Olson LJ, Pickering TG, Russell R, Woo M, Young T; American
Heart Association Council for High Blood Pressure Research Professional Education
Committee, Council on Clinical Cardiology; American Heart Association Stroke
Council; American Heart Association Council on Cardiovascular Nursing; American College of Cardiology Foundation. Sleep apnea and cardiovascular disease: an American Heart Association/American College Of Cardiology Foundation Scientific Statement from the American Heart Association Council for High Blood Pressure Research Professional Education
Committee, Council on Clinical Cardiology, Stroke Council, and Council On
Cardiovascular Nursing. In collaboration with the National Heart, Lung, and Blood
Institute National Center on Sleep Disorders Research (National Institutes of
Health).
Circulation. 2008 Sep 2;118(10):1080-111. [PMID: 18725495]
Wellman A, Malhotra A, Jordan AS, Stevenson KE, Gautam S, White DP. Effect of oxygen in obstructive sleep apnea: role of loop gain.
Respir Physiol Neurobiol. 2008 Jul 31;162(2):144-51. [PMID: 18577470]
Wilkinson V, Malhotra A, Nicholas CL, Worsnop C, Jordan AS, Butler JE, Saboisky JP, Gandevia SC, White DP, Trinder J. Discharge patterns of human genioglossus motor units during sleep onset.
Sleep. 2008 Apr 1;31(4):525-33. [PMID: 18457240]
Saboisky JP, Butler JE, McKenzie DK, Gorman RB, Trinder JA, White DP, Gandevia SC. Neural drive to human genioglossus in obstructive sleep apnoea.
J Physiol. 2007 Nov 15;585(Pt 1):135-46. [PMID: 17916615]
Chamberlin NL, Eikermann M, Fassbender P, White DP, Malhotra A. Genioglossus premotoneurons and the negative pressure reflex in rats.
J Physiol 2007; 579(Pt 2):515-526. [PMID: 17185342]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical control stability in the elderly.
J Physiol 2007; 581(Pt 1):291-298. [PMID: 17317747]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikerman M, Schory K, Dover L, White DP. The Influence of Wakefulness on Pharyngeal Airway Muscle Activity.
Thorax. 2007 Mar 27; Epub ahead of print. [PMID: 17389755]
Jordan AS, Heinzer R, Lo Y, Schory K, Dover L, Gautam S, Malhotra A, and White DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans.
Thorax. 2007 Apr 5; [Epub ahead of print] [PMID: 17412778]
Wellman A, Malhotra A, Jordan AS, Schory K, Gautam S, White DP. Chemical Control Stability in the Elderly.
J Physiol. 2007 May 15;581(Pt 1):291-8. Epub 2007 Feb 22. [PMID: 17317747]
Heinzer RC, Stanchina ML, Malhotra A, Jordan AS, Patel SR, Lo YL, Wellman A, Schory K, Dover L, White DP. Effect of increased lung volume on sleep disordered breathing in patients with sleep apnoea.
Thorax. 2006 May;61(5):435-9. Epub 2006 Feb 20. [PMID: 16490766]
Lo YL, Jordan AS, Malhotra A, Wellman A, Heinzer RC, Schory K, Dover L, Fogel RB, White DP. Genioglossal muscle response to CO2 stimulation during NREM sleep.
Sleep. 2006 Apr 1;29(4):470-7. [PMID: 16676780]
Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB. Correlates of long sleep duration.
Sleep 2006; 29:881-9. [PMID: 16895254]
Patel SR, Malhotra A, White DP, Gottlieb DJ, Hu FB. Association between Reduced Sleep and Weight Gain in Women.
Am J Epidemiol 2006; 164(10):947-954. [PMID: 16914506]
Malhotra A, Huang Y, Pillar G, White DP. Aging and Menopausal Influences on Pharyngeal Anatomy and Physiology: The predisposition to Sleep Apnea.
American Journal of Medicine, 2006; 119: 72.e9-72.e14.
Malhotra A, Huang Y, Fogel RB, Lazic S, Pillar G, Jakab M, Kikinis R, White DP. Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse.
Am J Med 119:72e9-72e14, 2006. [PMID: 16431197]
Jordan AS, Wellman A, Edwards JK, Schory K, Dover L, MacDonald M, Patel SR, Fogel RB, Malhotra A, White DP. Respiratory control stability and upper airway collapsibility in men and women with obstructive sleep apnea.
J Appl Physiol. 2005 Nov;99(5):2020-7 [PMID: 15994243 ]
Heinzer RC, Stanchina ML, Malhotra A, Fogel RB, Patel SR, Jordan AS, Schory K, White DP. Lung volume and continuous positive airway pressure requirements in obstructive sleep apnea.
Am J Respir Crit Care Med. 2005 Jul 1;172(1):114-7. [PMID: 15817803]
Huang Y, Malhotra A, White DP. Computational Simulation of Human Upper Airway Collapse Using a Pressure/State-Dependent Model of Genioglossal Muscle Contraction under Laminar Flow Condition.
Journal of Applied Physiology, 2005; 99 (3): 1138-1148. [PMID: 15831800]
Huang Y, Malhotra A, White DP. Computational simulation of human upper airway collapse using a pressure -/state-dependent model of genioglossal muscle contraction under laminar flow conditions.
J Appl Physiol 2005 Sep; 99(3):1138-48. [PMID: 15831800]
Fogel RB, Trinder J, White DP, Malhotra A, Raneri J, Schory K, Kleverlaan D, Pierce RJ. The effect of sleep onset on upper airway muscle activity in patients with sleep apnea versus controls.
J Physiol 2005 Apr 15;564(Pt 2):549-62. [PMID: 15695240]
Wellman A, Jordan AS, Malhotra A, Fogel RB, Katz ES, Schory K, Edwards JK, White DP. Ventilatory control and airway anatomy in obstructive sleep apnea.
Am J Respir Crit Care Med. 2004 Dec 1;170(11):1225-32. Epub 2004 Aug 18. [PMID: 15317668]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: Results of a meta-analysis.
Sleep 2004; 27: 249-53. [PMID: 15124718]
Patel SR, Palmer LJ, Larkin EK, Jenny NS, White DP, Redline S. Relationship between obstructive sleep apnea and diurnal leptin rhythms.
Sleep 2004; 27: 235-9. [PMID: 15124716]
Patel SR, Ayas NT, Malhotra MR, White DP, Schernhammer ES, Speizer FE, Stampfer MJ, Hu FB. A prospective study of sleep duration and mortality risk in women.
Sleep 2004; 27:440-4. [PMID: 15164896]
Malhotra A, Trinder J, Fogel R, Stanchina M, Patel SR, Schory K, Kleverlaan D, White DP. Postural effects on pharyngeal protective reflex mechanisms.
Sleep 2004; 27: 1105-12. [PMID: 15532204]
McGuire M, Zhang Y, White DP and Ling L. Serotonin Receptor Subtypes Required for Ventilatory Long-Term Facilitation and Its Enhancement after Chronic Intermittent Hypoxia in Awake Rats.
Am J Physiol Regul Integr Comp Physiol. 2004; 286(2):R334-41. [PMID: 14551171]
Jordan AS, McEvoy RD, Edwards JK, Schory K, Yang C-K, Catcheside PG, Fogel RB, Malhotra A, White DP. The influence of gender and upper airway resistance on the ventilatory response to arousal in obstructive sleep apnoea in humans. J Physiol (London) 2004 Aug 1;558(Pt 3):993-1004. [PMID: 15218069]
Ayas NT, Patel SR, Malhotra A, Schulzer M, Malhotra M, Jung D, Fleetham J, White DP. Auto-titrating versus standard continuous positive airway pressure for the treatment of obstructive sleep apnea: results of a meta-analysis.
Sleep 2004 Mar 15;27(2):249-53. [PMID: 15124718]
Fogel RB, Trinder JH, White DP, Malhotra A, Kleverlaan D, and Pierce RJ. Control of Upper Airway Muscle Activity During Sleep Onset in Patients with Sleep Apnea Versus Controls.
Annual APSS Meeting, Philadelphia, 2004. [PMID: 15695240]
Wellman A, Malhotra A, Fogel RB, Edwards JK, Schory K, and White DP. Respiratory system loop gain in normal men and women measured with proportional-assist ventilation.
J Appl Physiol 94: 205-212, 2003. [PMID: 12391042]
Ayas NT, White DP, Al-Delaimy WK, Manson JE, Stampfer MJ, Speizer FE, Patel SR, Hu FB. A prospective study of self-reported sleep duration and incident diabetes in women.
Diabetes Care 2003; 26:380-4. [PMID: 12547866]
Patel SR, White DP, Malhotra, A, Stanchina ML, Ayas NT. Continuous positive airway pressure therapy for treating sleepiness in a diverse population with obstructive sleep apnea: results of a meta-analysis.
Arch Intern Med 2003, 163:565-71. [PMID: 12622603]
Stanchina ML, Malhotra A, Fogel RB, Edwards JK, Schory K, White DP. The impact of changing lung volumes on CPAP requirements in OSA patients.
Am J Resp Crit Care Med, 2003.
Fogel RB, Trinder J, Malhotra A, Stanchina ML, Edwards JK, Schory KE, White DP. Within-breath control of genioglossal muscle activation in humans: effect of sleep-wake state.
J Physiol (Lond) 2003; e-pub ahead of print. [PMID: 12807995]
Stanchina ML, Malhotra A, Fogel RB, Trinder J, Ayas N, Edwards JK, Schory K, White, DP. The influence of lung volume on pharyngeal mechanics, collapsibility, and genioglossus muscle activation during sleep.
Sleep 2003 Nov 1;26(7):851-6. [PMID: 14655919]
Fogel R, White DP, Pierce R, Malhotra A, Edwards J, Dunai J, Kleverlaan D, Trinder J. Control of upper airway muscle activity in younger versus older men during sleep onset.
J Physiol 2003 Dec 1;553(Pt 2):535-44. [PMID: 12963804]
Ayas N, White DP, Manson J, Stampfer MJ, Speizer FE, Malhotra A, Hu F. A prospective study of sleep duration and coronary heart disease in women. Arch of Intern Med 2003 Jan 27;163(2):205-9. [PMID: 12546611]
Stanchina M, Malhotra A, Fogel R, Ayas, N, Edwards JK, Schory K, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during non-rapid eye movement sleep.
Am J Respir Crit Care Med 2002, 165:945-9. [PMID: 11934719]
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring S, White DP. The Male Gender Predisposition to Obstructive Sleep Apnea: Importance of Airway Length.
American Journal of Respiratory and Critical Care Medicine 2002; 166: 1388-1395. [PMID: 12421747]
Malhotra A, Pillar G, Fogel RB, Edwards JK, Ayas N, Akahoshi T, Hess D, White DP. Pharyngeal pressure and flow efects on genioglossus activation in normal subjects.
Am J Resp Crit Care Med 165: 71-77, 2002. [PMID: 11779733]
Malhotra A, Huang Y, Fogel R, Pillar G, Edwards JK, Kikinis R, Loring SH, White DP. The Male predisposition to pharyngeal collapse: Importance of airway length.
Am J Resp Crit Care Med 166: 1388-95, 2002. [PMID: 12421747]
Stanchina M, Malhotra A, Fogel R, Edwards JK, Schory K, Ayas N, White DP. Genioglossal muscle responsiveness to chemical and mechanical loading during NREM sleep.
Am J Respir Crit Care Med 2002 Apr 1;165(7):945-9. [PMID: 11934719]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards J, Ayas N, Hess D, White DP. Pharyngeal pressure and flow effects on genioglossus activation in normal subjects.
Am J Respir Crit Care Med 2002;Jan 1;165(1):71-7. [PMID: 11779733]
Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome.
J Clin Endocrinol Metab, 86: 1175-80, 2001. [PMID: 11238505]
Fogel RB, Malhotra A, Pillar G, Edwards JK, Beauregard J, Shea SA, White DP. Genioglossal activation in patients with obstructive sleep apnea versus controls: mechanisms of muscle control.
Am J Respir Crit Care Med 2001, 164:2025-30. [PMID: 11739130]
Pillar G, Fogel R, Malhotra A, Beauregard J, Edwards JK, Shea SA, White DP. Genioglossal inspiratory activation: central respiratory versus mechanoreceptive influences.
Respir Physiol 2001, 127:23-38. [PMID: 11445198]
Malhotra A, Pillar G, Fogel R, Beauregard J, Edwards JK, Slamowitz DI, Shea SA, White DP. Genioglossal but not palatal muscle activity relates closely to pharyngeal pressure. Am J Respir Crit Care Med 2000;162:1058-62. [PMID: 10988130]
Pillar G, Malhotra A, Fogel RB, Beauregard J, Slamowitz DI, Shea SA, White DP. Upper airway muscle responsiveness to rising PCO2 during non-REM sleep.
J Appl Physiol, 89:1275-82, 2000. [PMID: 11007559]
Pillar G, Malhotra A, Fogel RB, Beauregard J, Schnall R, White DP. Airway mechanics and ventilation in response to resistive loading during sleep: Influence of gender.
Am J Resp Crit Care Med, 162:1627-32, 2000. [PMID: 11069787]
Malhotra A, Fogel R, Edwards J, Shea S, White DP. Local mechanisms drive pharyngeal muscle dilator activation in obstructive sleep apnea.
Am J Respir Crit Care Med 2000;161:1746-9. [PMID: 10806181]
Fogel RB, Malhotra A, Shea SA, Edwards JK, White DP. Reduced genioglossal activity with upper airway anesthesia in awake patients with OSA.
J Appl Physiol 2000;88:1346-54. [PMID: 10749829]
Book Chapters
Stanchina ML, Malhotra A, White DP. Diagnosis and treatment of respiratory disorders of sleep.
Textbook of Pulmonary Diseases, Crapo, Schwartz, King, Karlinsky editors, 2003.
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