Research on Circadian Rhythms in Health and Disease
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Plamen Ch. Ivanov, Ph.D.
Lecturer in Medicine, Harvard Medical School
Associate Physiologist, Brigham & Women's Hospital
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|
Institution and Location |
Degree |
Year(s) |
Field of Study |
| Sofia University; Bulgaria | M.S. | 1988 | Theoretical Physics / Condensed Matter Physics |
| Sofia University; Bulgaria | M.S. | 1990 | International Relations |
| Boston University; Boston, MA USA | Ph.D. | 1998 | Biophysics |
| 1989-1991 | Research Assistant, Institute of Solid State Physics, Bulgarian Academy of Sciences, Sofia | |
| 1993-1996 | Teaching Assistant, Physics Department, Boston University | |
| 1996-1998 | Research Assistant, Center for Polymer Studies, Boston University | |
| 1998-1999 | Postdoctoral Fellow, Harvard Medical School, Beth Israel Deaconess Medical Center, Laboratory for Nonlinear Dynamics in Medicine, and Boston University, Center for Polymer Studies | |
| 1999-present | Senior Research Associate, Center for Polymer Studies, Boston University | |
| 2003-present | Associate Professor (on extended leave), Institute of Solid State Physics, Condensed Matter Theory Group, Bulgarian Academy of Sciences, Sofia | |
| 1999-2004 | Research Associate, Harvard Medical School, Beth Israel Deaconess Medical Center, Margaret and H.A. Rey Laboratory for Nonlinear Dynamics in Medicine | |
Honors and Awards:
| 1985-1988 | Bulgarian Ministry of Education M.Sc. Scholarship for high academic achievement, Sofia University | |
| 1988 | Sofia University Gold Medal for Scholarship (top student in Physical Sciences over the 5-year course of studies) | |
| 1998 | NSF Young Scientist Travel Award, IUPAP International Conference on Statistical Physics 20, Paris, France | |
Selected Bibliography:
Publications: 57 articles in scientific journals (including 3 papers in Nature,
3 papers in Proc. Natl. Acad. Sci. USA, 7 papers in Physical Review Letters),
16 articles in conference proceedings, 5 book chapters.
Original Articles
1. P.Ch. Ivanov, M.G. Rosenblum, C-K Peng, J. Mietus, S. Havlin, H.E. Stanley, A.L. Goldberger. Scaling behaviour of heartbeat intervals obtained by wavelet-based time-series analysis. Nature, 1996; 383:323--327.
2. P.Ch. Ivanov, L.A.N. Amaral, A.L. Goldberger, H. E. Stanley. Stochastic feedback and the regulation of biological rhythms. Europhysics Letters, 1998; 43:363--368.
3. L.A.N. Amaral, A.L. Goldberger, P.Ch. Ivanov, H. E. Stanley. Scale-independent measures and pathologic cardiac dynamics. Physical Review Letters, 1998; 81:2388--2391.
4. P.Ch. Ivanov, M.G. Rosenblum, L.A.N. Amaral, Z.R. Struzik, S. Havlin, A.L. Goldberger, H.E. Stanley. Multifractality in human heartbeat dynamics. Nature, 1999; 399:461--465.
5. P.Ch. Ivanov, A. Bunde, L.A.N. Amaral, S. Havlin, J. Fritsch-Yelle, R.M. Baevsky, H.E. Stanley, A.L. Goldberger. Sleep-wake differences in scaling behavior of the human heartbeat: analysis of terrestrial and long-term space flight data. Europhysics Letters, 1999; 48:594-600.
6. A.L. Goldberger, L.A.N. Amaral, L. Glass, J.M. Hausdorff, P.Ch. Ivanov, R.G. Mark, J.E. Mietus, G.B. Moody, C.-K. Peng, H.E. Stanley. PhysioBank, PhysioToolkit, and PhysioNet: components of a new research resource for complex physiologic signals. Circulation, 2000; 101:e215.
7. P. Bernaola-Galvan, P.Ch. Ivanov, L.A.N. Amaral, H.E. Stanley. Scale Invariance in the Nonstationarity of Human Heart Rate. Physical Review Letters, 2001; 87(16):168105(4).
8. P.Ch. Ivanov, L.A.N. Amaral, A.L. Goldberger, S. Havlin, M.G. Rosenblum, H.E. Stanley, Z. Struzik, From $1/f$ Noise to Multifractal Cascades in Heartbeat Dynamics. Chaos, 2001; 11:641-652.
9. A.L. Goldberger, L.A.N. Amaral, J.M. Hausdorff, P.Ch. Ivanov, C.-K. Peng, H.E. Stanley. Fractal dynamics in physiology: alterations with disease and aging. Proc. Natl. Acad. Sci. USA, 2002; 99 [suppl 1]:2466-2472.
10. J.W. Kantelhardt, Y. Ashkenazy, P.Ch. Ivanov, A. Bunde, S. Havlin, T. Penzel, J.-H. Peter, H.E. Stanley. Characterization of sleep stages by correlations in the magnitude and sign of heartbeat increments. Physical Review E, 2002; 65:051908(6).
11. C.-C. Lo, L.A.N. Amaral, S. Havlin, P.Ch. Ivanov, T. Penzel J.-H. Peter, H.E. Stanley, Scale-free dynamics of awakenings during healthy human sleep. Europhysics Letters, 2002; 57(5): 625-631.
12. J.W. Kantelhardt, S. Havlin, P.Ch. Ivanov. Modeling transient correlations in heartbeat dynamics during sleep. Europhysics Letters, 2003; 62(2): 147-153.
13. K. Hu, P.Ch. Ivanov, Z. Chen, M.F. Hilton, H.E Stanley, S.A. Shea. Intrinsic Patters of Human Activity: Scaling and Nonlinear Dynamics in Forearm Motion. Physica A, 2004; 337: 307.
14. C.-C. Lo, T. Chou, T. Penzel, T. Scammell, R.E. Strecker, H.E. Stanley, and P.Ch. Ivanov. Common scale-invariant patterns of sleep-wake transitions across mammalian species. Proc. Natl. Acad. Sci., 2004; 101: 17545--17548.
15. K. Hu, P.Ch. Ivanov, M.F. Hilton, Z. Chen, R.T. Ayers, H.E. Stanley, S.A. Shea. Endogenous circadian rhythm in an index of cardiac vulnerability independent of changes in behavior.(shared first authorship with K.Hu) Proc. Natl. Acad. Sci., 2004; 101(52): 18223-18227.
16. Y. Ashkenazy, P.Ch. Ivanov, S. Havlin, C.-K. Peng, A.L. Goldberger, H.E. Stanley. `Magnitude and sign correlations in heartbeat fluctuations'. Physical Review Letters, 2001; 86(9):1900--1903.
17. V. Schulte-Frohlinde, Y. Ashkenazy, P.Ch. Ivanov, L. Glass, A.L. Goldberger, H.E. Stanley. `Noise effects on the complex patterns of abnormal heartbeats'.Physical Review Letters, 2001; 87(6):068104(4).
18. Y. Ashkenazy, J.M. Hausdorff, P.Ch. Ivanov, H.E. Stanley. `A stochastic model of human gait dynamics'. Physica A, 2002; 316: 662-670.
19. Z. Chen, K. Hu, P. Carpena, P. Bernaola-Galvan, H.E. Stanley, and P.Ch. Ivanov. Effect of nonlinear filters on detrended fluctuation analysis. Physical Review E, 2005; 71(1): 011104(11).
Reviews, Editorials, and Book Chapters
1. P.Ch. Ivanov, A.L. Goldberger, S. Havlin, C.-K Peng, M. G. Rosenblum, H. E. Stanley. Wavelets in Medicine and Physiology in Wavelets in Physics, editor J.C. van den Berg (Cambridge University Press, Cambridge, 1998)
2. P.Ch. Ivanov, A.L. Goldberger, H.E. Stanley. Fractal and Multifractal Approaches in Physiology in The Science of Disasters: Climate Disruptions, Heart Attacks, and Market Crashes, editors A. Bunde, J. Kropp and H.-J. Schellnhuber (Springer Verlag, Berlin, 2002) pp. 219-257.
3. P.Ch. Ivanov and C.C. Lo. Stochastic Approaches to Modeling of Physiological Rhythms in Modelling Biomedical Signals, editors G. Nardulli and S. Stramaglia (World Scientific, Singapore, 2002) pp. 28-50.
4. P.Ch. Ivanov. Long-Range Dependence in Heartbeat Dynamics in Processes with Long-Range Correlations: Theory and Applications, [Lecture Notes in Physics 621], editors G. Rangarajan and M. Ding (Springer Verlag, Berlin, 2003) pp. 339-368.
5. P.Ch. Ivanov. Random Walks in Physiologic Dynamics in Advances in Condensed Matter and Statistical Physics, editors E. Korutcheva and R. Cuerno (Nova Science Publishers, New York, 2004) pp.155-175.
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