Research on Circadian Rhythms in Health and Disease
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Atul Malhotra, M.D.
Assistant Professor in Medicine, Harvard Medical School
Associate Physician, Brigham and Women's Hospital
Staff Physician, Beth Israel Deaconess Medical Center
E-mail: amalhotra1@partners.org
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Institution and Location |
Degree |
Year(s) |
Field of Study |
| University of Alberta; Edmonton, Canada | B.Sc. | 1988 | Chemistry |
| University of Alberta; Edmonton, Canada | M.D. | 1992 | Medicine |
| St. Thomas Medical Center; Akron, OH USA | Internship | 1993 | Rotating |
| Mayo Clinic; Rochester, MN USA | Residency | 1996 | Internal |
| Harvard Combined Massachusetts General Hospital/Brigham and Women’s Hospital/Beth Israel Deaconess Medical Center, Boston, MA USA | Fellowship | 1998 | Pulmonary and Critical Care and Sleep Disorders Medicine |
| Brigham and Women’s Hospital, Boston, MA USA | Fellowship | 2000 | Sleep Medicine |
| 1999 – present | Staff Physician, Sleep Health Centers | |
| 1999 – present | Attending Physician, Medical Intensive Care Unit, West Roxbury VA Medical Center | |
| 2000 – present | Assistant in Medicine, Medical ICU and supervisor of Fellows' Clinic, Massachusetts General Hospital | |
| 2000 – present | Associate Physician, Surgical ICU and Interstitial Lung Disease Clinic, Brigham and Women's Hospital | |
| 2000 – 2003 | Instructor in Medicine, Harvard Medical School, Boston, MA | |
| 2003 – present | Assistant Professor of Medicine, Harvard Medical School, Boston, MA | |
| 2003 – present | Staff Physician, Beth Israel Deaconess Medical Center | |
| 2003 – present | Assistant Physician, Brigham and Women’s Hospital, Divisions of Sleep and Pulmonary and Critical Care Medicine | |
| 2006 – present | Medical Director, Sleep Disorders Program, Brigham and Women's Hospital |
Professional Memberships:
| 1996-present | American Thoracic Society (ATS) | |
| 1996-present | American College of Chest Physicians (ACCP) | |
| 1997-present | American Sleep Disorders Association (ASDA/AASM) | |
| 1997-present | Society for Critical Care Medicine (SCCM) | |
| 1999-present | Fellow of the Royal College of Physicians of Canada | |
| 2001-present | Program Committee Member Respiratory Neurobiology & Sleep, American Thoracic Society | |
| 2004-2006 | Program Chair, Respiratory Neurobiology and Sleep Committee at the ATS, elected position | |
| 2005 | Director, National Sleep Medicine Course, American Academy of Sleep Medicine | |
| 2006 | Chairman of the Education Committee, American Thoracic Society, presidential appointment | |
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1984-1988 |
Province of Alberta Scholarship, First Class Standing and named to Dean’s Honor Roll three of four years in undergraduate sciences |
|
1992 |
Rajcoomarie Singh Memorial Achievement Award upon graduation from medical school |
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1992 |
CIBA book prize for academic achievement upon graduation from medical school |
|
1992 |
Graduated with first class standing from medical school |
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1992-1993 |
Intern of the Year, St. Thomas Medical Center, Akron, Ohio |
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1993-1994 |
Outstanding Teacher of medical students, Mayo Medical School |
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1996 |
Gold Medal, Outstanding Achievement Award for medical residents, Mayo Clinic, Rochester, MN |
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2000 |
Trainee Research Merit Award, Associated Professional Sleep Societies, Las Vegas, Nevada |
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2001-2002 |
Teacher of the Year Award for medical residents, Department of Medicine, Massachusetts General Hospital, Boston, MA. |
|
2001-2002 |
Teacher of the Year Award for Pulmonary and Critical Care Fellows, Harvard Medical School Combined Program (Massachusetts General Hospital, Brigham and Women’s Hospital, Beth Israel Deaconess Medical Center, West Roxbury VA Medical Center), Boston, MA |
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2001 |
Marquis’ Who’s Who in America |
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2003 |
National Register’s Who’s Who in Executives and Professionals |
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2003 |
International Health Professional of the Year 2003, International Biographic Centre, Cambridge, UK |
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2005 |
Young Investigator Award, RNS Assembly, American Thoracic Society International Conference 2005, San Diego, California |
Selected Bibliography:
Original Manuscripts (selected from over 60 manuscripts since 2001)
1. Malhotra, A. et al., Upper airway collapsibility: measurement and sleep effects, Chest 2001, 120:156-161.
2. Fisher, D., Pillar, G., Malhotra, A., et al., Long-term follow-up of untreated patients with OSAS, Respir. Med. 2002, 96: 337-343.
3. Hilton, M.F., Chappell, M.J., Bartlett, W.A., Malhotra, A., Beattie, J.M., and Cayton, R.M., The Sleep Apnea/Hypopnea Syndrome Depresses Waking Vagal Tone Independent of Sympathetic Activation, Eur. Respir. J. 2001, 17:1-9.
4. Pillar, G., Fogel, R., Malhotra, A. et al., Genioglossal Inspiratory Activation: Central Respiratory versus Mechanoreceptive Influences, Respiration Physiology 2001, 127: 23-38.
5. Malhotra, A. et al , Pharyngeal Pressure and Flow Effects on Genioglossus Activation in Normal Subjects, AJRCCM 2002, 165:71-77.
6. Pittman, S.D., Hill, P.D., Malhotra, A. et al., Stabilizing Cheyne Stokes Respiration Associated with Congestive Heart Failure Using Computer-Assisted Positive Airway Pressure, Computers in Cardiology 2000, 27: 201-204.
7. Stanchina, M., Malhotra, A. et al, Genioglossal Muscle Responsiveness to Chemical and Mechanical Loading during NREM Sleep, Am. J. Respir. Crit. Care Med. 2002, 165: 945-950.
8. Malhotra, A. et al CPC: An 82 year old man with dyspnea and pulmonary abnormalities, NEJM 2003, 348:1574-1585.
9. Ayas, N, White, DP, Manson, J., Stampfer, MJ, Speizer, FE, Malhotra, A., Hu, F., A Prospective Study of Sleep Duration and Coronary Heart Disease in Women, Archives of Internal Medicine 2003, 163:205-209.
10. Patel, SR, White, DP, Malhotra, A., et al Continuous Positive Airway Pressure Therapy for Treating Sleepiness in a Diverse Population With Obstructive Sleep Apnea: Results of a Meta-analysis, Archives of Internal Medicine 2003, 163:565-571.
11. Snow, A., Gozal, E., Malhotra, A., et al, Severe hypersomnolence after pituitary/hypothalamic surgery in children: Clinical characteristics and potential mechanisms, Pediatrics 2002, 110/E74:1-6.
12. Malhotra, A., et al The Male Predisposition to Obstructive Sleep Apnea–Importance of Airway Length, Amer. J. Respir. Crit. Care Med. 2002, 166: 1388-1395. (International Press Release by Reuters Health)
13. Wellman, A., Malhotra, A., Respiratory System Loop Gain in Normal Men and Women measured with PAV, JAP, 2003, 94: 205-212.
14. Pillar, G., Schuscheim, G., Weiss, R., Malhotra, A., et al, Interactions between hypoglycemia and sleep architecture in children with type 1 diabetes mellitus, J. Ped. 2003, 142: 163-168.
15. Berry, RB, White, DP, Roper, J., Pillar, G., Fogel, RB, Stanchina, M, and Malhotra, A., Negative Pressure Reflex Response of the Genioglossus in OSA Patients and Normal Subjects, J. Appl. Physiol. 2003, 94: 1875-1882.
16. Huang, Y., Malhotra, A., White, DP, A computational model of upper airway collapsibility, IEEE 2003.
17. Stanchina, ML, Malhotra, A. et al, The Influence of Changing Lung Volumes on Upper Airway Mechanics and Genioglossus Muscle Activation during Sleep, SLEEP 2003, 26: 851-856.
18. Ayas, NT, Patel, SR, Malhotra, A, et al Auto-Titrating versus Standard Continuous Positive Airway Pressure for the Treatment of Obstructive Sleep Apnea: Results of a Meta-analysis, SLEEP 2004, 27: 249-253.
19. Pittman, SD et al, Diagnosing Obstructive Sleep Apnea with a Wrist-Worn Device Based on Peripheral Arterial Tonometry: In-Laboratory Polysomnographic Validation and Ambulatory Studies in the Home, SLEEP 2004, 27:923-933.
20. Malhotra, A., et al, Postural Effects on Pharyngeal Protective Reflex Mechanisms, SLEEP 2004, 27:1105-12.
21. Wellman, A, Jordan, AS, Malhotra, A. et al, Ventilatory control and airway anatomy in OSA, AJRCCM 2004, 170: 1225-1232.
22. Jordan, AS et al., The Influence of Gender and Upper airway resistance on the ventilatory response to arousal in obstructive sleep apnea, J Physiol. 2004, 558: 993-1004.
23. Aloia MS, Stanchina M, Arnedt JT, Malhotra A, Millman RP: Treatment adherence and outcomes in flexible versus standard continuous positive airway pressure therapy. Chest 2005, 127: 2085-2093.
24. Malhotra, A, et al, Aging Influences on Pharyngeal Anatomy and Physiology: The Predisposition to Pharyngeal Collapse, American Journal of Medicine 2006, 19- 72: 9-14.
25. Heinzer, RC, Stanchina, ML, Malhotra, A, et al, Lung volume and CPAP Requirements in OSA, AJRCCM, 2005, 172: 114-117.
26. Huang, Y., Malhotra, A., White, DP, A pressure and state-dependent muscle contraction model and its application in the computational simulation of upper airway collapse, J. Appl. Physiol. 2005, 99: 1138-1148.
27. Huang, Y, White, DP, Malhotra, A., The Impact of Anatomical Manipulations on Upper Airway Collapse in Humans: Results from a Computational Model, Chest 2005, 128: 1324-1330.
28. Caramez, MP, Borges, JB, Okamoto, VN, Tucci, MR, Carvalho, CRR, Kacmarek, RM, Malhotra, A, Velasco, IR, Amato, MBP, Paradoxical Responses to PEEP in Patients with Airways Obstructive during Controlled Ventilation, CCM 2005, 33: 1519-1528.
29. Yinon, D, et al. G, Pre-eclamptic toxemia is associated with sleep disordered breathing and endothelial dysfunction, Eur Respir J. 2006 Feb;27(2):328-33.
30. Lo, YL et al. Genioglossal muscle response to CO2 stimulation during NREM sleep, Sleep 2006; 29:470-7
31. Malhotra, A. Intensive Insulin in Intensive Care, invited editorial, NEJM 2006, 354: 516-518.
32. Heinzer, R, Jordan, A, Malhotra, A, Wellman, A, Lo, Y, Patel, S, Schory, K, Dover, L, White, DP, Effect of Increased Lung Volume on Sleep Disordered Breathing in Sleep Apnea patients, Thorax 2006, 61:435-9.
33. Patel SR, Malhotra A, Gottlieb DJ, White DP, Hu FB., Correlates of Long Sleep Duration, SLEEP 2006, 29: 881-889.
34. Patel, SR, Malhotra, A, et al Reduced sleep is a risk factor for weight gain, Amer J Epi 2006, 164: 947-954
35. Chamberlin, NL, Eikermann, M, Fassbender, P, White, DP, and Malhotra, A, Genioglossus Premotoneurons and the Negative Pressure Reflex in Rats, J. Physiol. in press.
36. Huang, Y, White, DP, Malhotra, A, The Use of Computational Modeling to Predict Responses to Upper Airway Surgery in Obstructive Sleep Apnea, The Laryngoscope, i2007, 117: 648-653.
37. Wellman, A, Malhotra, A et al, Chemical Control Stability in the Elderly, J. Physiol., in press.
38. Ronen, O, Malhotra, A, Pillar, G. The influence of gender and age on upper airway length during development, Pediatrics, in press.
39. Eikermann, M, Jordan, AS, Chamberlin, NL, White, DP, Gautam, S., Wellman, DA, Lo, Y, and Malhotra, A. The Influence of Aging on Upper Airway Collapsibility during Sleep, Chest, in press.
40. Lo, Y, Jordan, A., Wellman, A, Eikermann, M, Schory, K, Dover, L, Malhotra, A, White, DP. The Influence of Wakefulness on Pharyngeal Airway Muscle, Thorax, in press.
41. Jordan, AS, Heinzer, R, Lo, Y, Schory, K, Dover, L, Gautam, S, Malhotra, A, and White, DP. Mechanisms Used To Restore Ventilation After Partial Upper Airway Collapse During Sleep In Humans, Thorax, in press.
42. Pierce, R, White, DP, Malhotra, A, Edwards, J, Kleverlaan, D, Palmer, LJ, Trinder, J, Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea, European Respiratory Journal in press.
43. Stanchina, ML, Ellison, K, Malhotra, A, Anderson, M, Kirk, M, Benser, ME, Tosi, C, Carlisle, C, Millman, RP, Buxton, A, The Impact of Cardiac Resynchronization Therapy on Obstructive Sleep Apnea in Heart Failure Patients: A Pilot Study, Chest in press.
Reviews, Chapters and Letters – Over 50 – Not listed;
Abstracts – Over 150 – Not listed
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